ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2756

Gender Differences in  Body Composition with Dual-Energy X-Ray Absorptiometry in TNF-α Blocker Naive Ankylosing Spondylitis Patients

Sebastián Ibáñez1,2, Ingrid M. Visman3, Christiaan van Denderen3, Willem F. Lems4,5, M. Nurmohamed4,6 and Irene van der Horst - Bruinsma4, 1Reumatología, Clínica Alemana de Santiago, Santiago, Chile, 2Reumatología, Hospital Padre Hurtado, Santiago, Chile, 3Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, 4Rheumatology, Amsterdam Rheumatology and immunology Center, VU University medical center, Amsterdam, Netherlands, 5Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, New Caledonia, 6Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Ankylosing spondylitis (AS), body mass, Dual energy x-ray absorptiometry (DEXA), sex bias and women's health

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Tuesday, November 15, 2016

Title: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster III

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Data on body composition (BC) in Ankylosing Spondylitis (AS) are sparse and controversial. Female AS patients have less response to TNF-α blockers and a shorter drug survival. This might be explained by differences in BC, as women have higher body fat (BF) levels and fat produces TNF-α. Our objective was to assess the BC in a cohort of AS patients naïve to TNF-α blockers, and to evaluate the differences between genders and with the reference population.

Methods: Patients included fulfilled the Modified New York criteria and were naïve to TNF-α blockers. Clinical assessments included age, disease duration, extra articular manifestations, therapies, hypertension, diabetes, dyslipidemia, lifestyle (tobacco, alcohol and marihuana use, physical activity), body mass index (BMI), ASDAS CRP and ESR, BASDAI, BASFI, BASMI. BC was assessed by whole body Dual-Energy X-ray Absorptiometry. BF%, Fat Mass Index (FMI), Fat Free Mass Index (FFMI), and android/gynoid (A/G) fat ratio were reported and compared with the reference population (percentiles, stratified by ethnicity, age and gender). Association between variables and differences between groups were assessed using t-test, Chi-Square, Mann-Whitney U test or linear regression depending on the variable.

Results: Seventy consecutive patients were included, 42 (62%) were men. The mean age was 43.9 (11.7 SD). By BMI 35.7% were overweight and 15.7% obese and there were no underweight patients. 62.9% had a BASDAI >4, and the median for ASDAS CRP was 3.4, for BASFI 4 and for BASMI 2. Disease duration, severity, extra articular manifestations, therapies, comorbidities and lifestyle were similar between men and women, except for dyslipidemia, present in 57.1% of men and in 14.3% of women (p<0.001). Women had a higher proportion of obese patients by BMI, higher BF % and FMI, and lower FFMI, but the percentile levels for BF% and FMI were similar to men, and better for FFMI. Men had a higher proportion of overweight patients and a higher A/G fat ratio (Table 1). After multivariate analysis, a higher A/G fat ratio was related to dyslipidemia in all patients. In men there was a significant association between BF% and categorical ASDAS CRP, and for FMI and FFMI with HTA. In women there was a significant association between FMI and categorical ASDAS ESR, and between FFMI and psoriasis. In the univariate analysis BASMI was significantly associated with BF% and FMI in men, and BASFI with BF % in women. 

Conclusion: Women had higher BF% and FMI than men, but when BF%, FMI and FFMI were compared to the reference population they had a better than average BC. For men it was the opposite, with a trend for higher BF% and FMI percentile levels than women. There was a trend between higher fat percentages and increased disease activity measurements. The association of A/G fat ratio and dyslipidemia was significant independently of sex, which might contribute to the increased cardiovascular risk in AS.

 


Disclosure: S. Ibáñez, None; I. M. Visman, None; C. van Denderen, None; W. F. Lems, None; M. Nurmohamed, None; I. van der Horst - Bruinsma, None.

To cite this abstract in AMA style:

Ibáñez S, Visman IM, van Denderen C, Lems WF, Nurmohamed M, van der Horst - Bruinsma I. Gender Differences in  Body Composition with Dual-Energy X-Ray Absorptiometry in TNF-α Blocker Naive Ankylosing Spondylitis Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/gender-differences-in-body-composition-with-dual-energy-x-ray-absorptiometry-in-tnf-%ce%b1-blocker-naive-ankylosing-spondylitis-patients/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/gender-differences-in-body-composition-with-dual-energy-x-ray-absorptiometry-in-tnf-%ce%b1-blocker-naive-ankylosing-spondylitis-patients/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology