ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2190

Features of Interstitial Lung Disease Associated with Connective Tissue Disease in a Spanish Southwest Cohort

Adela Gallego Flores1, Carmen Carrasco Cubero2, Raul Veroz Gonzalez1, Luz Maria Mellado Narciso1, Tamara Libertad Rodriguez Araya1, Juan Jose Aznar Sánchez1 and Eugenio Chamizo Carmona1, 1Rheumatology, Hospital de Mérida, Mérida, Spain, 2Rheumatology, Hospital de Merida, Mérida, Spain

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: autoimmune diseases, interstitial lung disease, pulmonary fibrosis and rheumatoid arthritis (RA)

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Miscellaneous Rheumatic and Inflammatory Diseases

Session Type: Abstract Submissions (ACR)

Background/Purpose

Diffuse interstitial lung disease (ILD) can be associated with connective tissue diseases (CTD), and can increase morbidity and mortality significantly. The predominant patterns of ILD associated with CTD are often nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP). UIP is more common in rheumatoid arthritis (RA). Pulmonary involvement in rheumatic diseases can be the first manifestation of these pathologies, preceding the onset of extrapulmonary symptoms. The presentation, clinical features and evolution of ILD associated with CTD can be variable, and therefore, it’s important to improve the prognosis by early diagnosis and treatment. The aim of this study is to describe the clinical features, treatments and outcome of patients with ILD associated with  CTD found in the General Hospital of Mérida.

Methods

We systematically collected all cases of ILD associated with CTD reported in the Rheumatology Department from January 2008 to January 2014. We included patients over 18 years old, who had a CTD and radiological diagnosis of ILD.

Results

We found 36 patients with ILD associated with CTD: 17 rheumatoid arthritis (RA), 10 scleroderma (ES), 6 antisynthetase syndromes (SAS) and 3 Sjögren’s syndrome (SS).  The mean age was 66.08 years, with a female predominance (2-1). History of smoking was present in 33.3% of the sample, and previous lung pathology in 18.7%. The diagnosis of CTD preceded the diagnosis of ILD in 58,3 % (21). The ILD patterns were: 17  NSIP  ( 47,2 %) , more frequent in ES (6 pac) and SAS (5 pac); and 19 UIP ( 52,8% ) , predominantly in RA .  Thirty patients were treated with IV cyclophosphamide (CF) and 14 with rituximab (RTX) . We observed a sustained response in 13 patients (10 NSIP and 3 UIP): 2 patients had received CF, 6 RTX, 4 CF+RTX, and 1 antiTNF. All RA patients were rheumatoid factor (RF) positive, 33,3 % with a title over 100. The predominant pattern was UIP (73,2 %). Methotrexate was used in 64.2% of patients and it was suspended at the diagnosis of ILD, although no cases of pneumonitis were found by this drug. Patients with ES, SAS and SS were younger at diagnosis (63.7, 62 and 64.3 years respectively) than RA patients (69,23 years) and a predominance of NSIP pattern (66.7, 80 and 66.6 % respectively). All these patients had negative RF. ANAs were positive in 100 % of SAS, with a predominance of anti Ro 52 and anti JO1 (3 and 4 patients) and 77.8% of ES and 66.6 % of SS. Two patients presented with poor responses to CF, one with UIP (ES) and 1 with NSIP (SAS), who died from infectious complications.

Conclusion

Usually the first manifestation of an ETC is due to the ILD, so it is advisable to maintain close cooperation with pneumologist. According to the literature, all patients with RA and ILD in our sample had RF+, as it usually occurs  in rheumatoid extraarticular involvement. Otherwise, the UIP was the predominant pulmonary pattern. Rest of ETC associated ILD had a predominance of NSIP pattern and positive ANAs, especially anti Ro, and anti Jo1 in SAS. The RF was negative in all cases. Nine patients treated with RTX or sequentially with CF + RTX achieved better response. However, more studies need to be undertaken to reach better conclusions on the ways forward in treatment.


Disclosure:

A. Gallego Flores,
None;

C. Carrasco Cubero,
None;

R. Veroz Gonzalez,
None;

L. M. Mellado Narciso,
None;

T. L. Rodriguez Araya,
None;

J. J. Aznar Sánchez,
None;

E. Chamizo Carmona,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/features-of-interstitial-lung-disease-associated-with-connective-tissue-disease-in-a-spanish-southwest-cohort/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology