Factors Associated with the 6-Minute Walk Distance in Patients with Systemic Sclerosis

Sébastien Sanges¹, Jonathan Giovannelli², Vincent Sobanski³, Céline Podevin², Sandrine Dubois-Morell², Hélène Maillard⁴, Marc Lambert⁴, Nicolas Lamblin⁵, Pascal De Groote⁵, Jean-François Bervar⁶, Pierre-Yves Hatron⁷, Eric Hachulla⁸ and David Launay⁹, ¹Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ²Service de Médecine Interne, Centre National de Référence de la Sclérodermie Sytémique, Lille, France, ³Univ. Lille, U995, Lille Inflammation Research International Center (LIRIC), F-59000 Lille, France, ⁴Department of internal medecine, Hôpital Claude Huriez, CHRU Lille, France, Lille, France, ⁵Service de Cardiologie, Lille, France, ⁶Service de Pneumologie, Lille, France, ⁷Univ Lille, CHU Lille, F-59000 Lille, France, Lille, France, ⁸CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ⁹Service de Médecine Interne, Centre National de Référence des Maladies Systémiques Rares, Hôpital Claude Huriez, CHRU Lille, Lille, France

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Pulmonary Involvement and systemic sclerosis

Session Information

Date: Monday, November 6, 2017

Title: Systemic Sclerosis, Fibrosing Syndromes and Raynaud's – Clinical Aspects and Therapeutics Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

To assess the associations between the 6-minute walk distance (6MWD) and various disease parameters in patients with systemic sclerosis (SSc).

Methods:

Consecutive patients followed in our SSc National Reference Centre were included in this cross-sectional study if they fulfilled the 2013 ACR/EULAR criteria for SSc. Data were prospectively collected during a comprehensive evaluation that included a 6-minute walk test, clinical assessment, biological results, pulmonary function tests, transthoracic echocardiography, composite scores (EScSG-AI, Medsger, HAQ-DI) and treatments.

Associations of the 6MWD with various disease parameters were assessed by linear regression in univariate analyses, then in several multivariate models.

Results:

The study population comprised 298 patients (females: 81%; mean age: 58.2 ± 13.3 years old; limited cutaneous SSc: 82%; interstitial lung disease (ILD): 42%; pulmonary arterial hypertension (PAH): 6%). The 6MWD was significantly and independently associated with gender, age, initial heart rate, heart rate variation during the test, PAH and CRP levels. Muscle involvement, joint involvement and ILD were not independently associated with the 6MWD.

Conclusion:

During SSc, the 6MWD is independently associated with heart rate variation (possibly implying a role for chronotropic incompetence in exercise intolerance), with PAH but not ILD (suggesting that pulmonary vasculopathy may have a greater impact than parenchymal involvement on functional limitation), and with global markers of disease activity. These results give further insight to clinicians on how to interpret the 6MWD in the context of SSc.

Disclosure: S. Sanges, None; J. Giovannelli, None; V. Sobanski, None; C. Podevin, None; S. Dubois-Morell, None; H. Maillard, None; M. Lambert, None; N. Lamblin, None; P. De Groote, None; J. F. Bervar, None; P. Y. Hatron, None; E. Hachulla, None; D. Launay, None.

To cite this abstract in AMA style:

Sanges S, Giovannelli J, Sobanski V, Podevin C, Dubois-Morell S, Maillard H, Lambert M, Lamblin N, De Groote P, Bervar JF, Hatron PY, Hachulla E, Launay D. Factors Associated with the 6-Minute Walk Distance in Patients with Systemic Sclerosis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/factors-associated-with-the-6-minute-walk-distance-in-patients-with-systemic-sclerosis/. Accessed .

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