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Abstract Number: 817

Extension of Affected Vascular Territories in Secondary Aortitis Is Associated to Different Clinical Subtypes?

Nuria Vegas-Revenga1, Javier Loricera1, Diana Prieto Peña1, Isabel Martínez-Rodríguez1, Jose Ignacio Banzo2, Monica Calderón Goercke3, Jesus Gonzalez- Vela1, Jose L. Hernández1, Vanesa Calvo-Río1, Lucia C. Domínguez-Casas1, José Luis Martín-Varillas3, Belén Atienza-Mateo3, MC Gonzalez-Vela1, Miguel Angel González-Gay1 and Ricardo Blanco3, 1Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Nuclear Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain

Meeting: ACR/ARHP Annual Meeting 2017

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Sunday, November 5, 2017

Title: Vasculitis Poster I: Large Vessel Vasculitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

Aortitis is characterized by inflammation of the aortic wall. Aortitis may be associated with different conditions.

Our aim was to assess if the different vascular territories affected in aortitis is associated to different underlying diseases or to different clinical subtypes.

Methods:

Retrospective study of 38 patients with non-infectious aortitis diagnosed by PET/CT. Whole-body FDG-PET uptake was assessed 180 minutes after injection of 7 MBq/Kg of 18F-FDG. Images were visually evaluated according to the intensity of the 18F-FDG uptake by the vessel wall at the supraaortic trunks (ST), thoracic aorta (TA), abdominal aorta (AA), iliac arteries (IA) and arteries of lower limbs (LL).

Results:

Thirty-eight patients (28 women/10 men) with a mean age of 68±11 years were assessed. The underlying conditions were: giant cell arteritis (n=24), Takayasu arteritis (n= 3), spondiloarthropathie (n=3), Sjögren syndrome (n=3), ulcerative colitis (n=2), sarcoidosis (n=1), rheumatoid arthritis (n=1), and polyarteritis nodosa (n=1).

A total of 190 vascular territories were evaluated, observing FDG-uptake in 122 (64.2%): ST (n=28, 22.3%), TA (n=38, 31.1%), AA (n=26, 21.3%), IA (n=13, 10.7%), and LL (n=17, 13.9%).

Four out of 38 patients (10.5%) had FDG-uptake in a single vascular territory (TA), 10 (26.3%) in 2 territories, 6 (15.8%) in 3, 10 (26.3%) in 4, and 8 (21.1%) in the 5 territories. The most common affection was observed in the 5 territories (n=8), ST/AA (n=6), ST/TA/AA/LL (n=5), ST/TA/AA (n=4) and ST/TA/AA/IA (n=4). Significative differences were observed between the extension of the affection (≤2 vs >2 territories) and the number of months from the symptoms onset to the diagnosis (79.1±59.9 vs 24.5±33.4 months; p=0.003). Differences regarding age, sex underlying disease, C-reactive protein, ESR, or treatment were not observed.

Conclusion:

In patients with secondary non-infectious aortitis, the PET/CT demonstrated a frequent involvement of several vascular territories in addition to aorta, mainly ST. The extension of the vascular affection did not relate to the severity of the clinical syndrome.


Disclosure: N. Vegas-Revenga, None; J. Loricera, None; D. Prieto Peña, None; I. Martínez-Rodríguez, None; J. I. Banzo, None; M. Calderón Goercke, None; J. Gonzalez- Vela, None; J. L. Hernández, None; V. Calvo-Río, None; L. C. Domínguez-Casas, None; J. L. Martín-Varillas, None; B. Atienza-Mateo, None; M. Gonzalez-Vela, None; M. A. González-Gay, None; R. Blanco, None.

To cite this abstract in AMA style:

Vegas-Revenga N, Loricera J, Prieto Peña D, Martínez-Rodríguez I, Banzo JI, Calderón Goercke M, Gonzalez- Vela J, Hernández JL, Calvo-Río V, Domínguez-Casas LC, Martín-Varillas JL, Atienza-Mateo B, Gonzalez-Vela M, González-Gay MA, Blanco R. Extension of Affected Vascular Territories in Secondary Aortitis Is Associated to Different Clinical Subtypes? [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/extension-of-affected-vascular-territories-in-secondary-aortitis-is-associated-to-different-clinical-subtypes/. Accessed .

ACR Meeting Abstracts - https://acrabstracts.org/abstract/extension-of-affected-vascular-territories-in-secondary-aortitis-is-associated-to-different-clinical-subtypes/