Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Results: The expression of LL-37 was significantly increased in muscle tissue and symptomatic skin in patients with PM/DM compared to that in HC. LL-37 was mainly expressed by neutrophils as confirmed with double staining. The expression of monoclonal LL-37 positively correlated to CD66b expression in both muscle and skin tissues in PM/DM patients(R=0.9 and 0.74 respectively, P<0.01). BDCA-2 positive pDCs was significantly increased in muscle tissue in patients when compared to HC. MxA was expressed in the same areas as LL-37, CD66b and BDCA-2, and positively correlated with CD66b expression in muscle tissue in all patients(R=0.59, P<0.05). Moreover, the muscular expression of LL-37 and CD66b correlated with increased serum creatine kinase levels(R=0.62 and 0.71 respectively, P<0.05). Monoclonal LL-37 expression in muscle tissue in patients with short disease duration correlated negatively to FI-2 score (P<0.05, R=0.77).
To cite this abstract in AMA style:Lu X, Tang Q, Lindh M, Agerberth B, Dastmalchi M, Lundberg IE, Wick C. Expression of Anti-Microbial Peptide LL-37 Correlates to the Activation of Type I Interferon Pathway in Patients with Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/expression-of-anti-microbial-peptide-ll-37-correlates-to-the-activation-of-type-i-interferon-pathway-in-patients-with-idiopathic-inflammatory-myopathies/. Accessed December 1, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/expression-of-anti-microbial-peptide-ll-37-correlates-to-the-activation-of-type-i-interferon-pathway-in-patients-with-idiopathic-inflammatory-myopathies/