ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2104

Exposure to Fine Particle Air Pollution and Anti-Nuclear Antibodies (ANA) in a Large Population-Based Sample

Sasha Bernatsky1, Audrey Smargiassi2, Lawrence Joseph3, Patrick Belisle3 and Marvin J. Fritzler4, 1Divisions of Rheumatology and Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Université de Montreal, Montreal, QC, Canada, 3Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 4Medicine, University of Calgary, Calgary, AB, Canada

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Tuesday, November 7, 2017

Session Title: Miscellaneous Rheumatic and Inflammatory Diseases Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Fine particle air pollution (PM2.5) has been associated with many conditions including systemic autoimmune rheumatic diseases. Our work has previously suggested an association between estimates of exposure to industrial emissions of PM2.5 and anti-Cyclic Citrullinated Peptide (CCP), but no one to date has assessed anti-nuclear antibodies (ANA). Our purpose was to determine the association of ANA with estimates of exposure to PM2.5 (industrial emissions recorded by Environment Canada, and estimates from satellite imagery).

Methods: We assessed 2304 subjects from a large general population cohort, drawn from four census metropolitan areas in the province of Quebec, Canada. Within these 2304 patients, we performed multivariable logistic regression models for the outcome of positive ANA, assessing for independent effects of PM2.5 exposure (PM2.5 emissions and PM2.5 satellite estimates), adjusting for age, sex, smoking, and self-reported French Canadian ancestry. Exposures were determined from baseline six digit postal code of residence, to industrial PM2.5 emitters, estimated using Environment Canada’s National Pollutant Release Inventory. Our analyses assessed tons of PM2.5 annual industrial emissions, distance to major industrial emitters (industry emitting more than an average of 100 tons of PM2.5) and regional satellite PM2.

Results: In multivariate analyses, the only variable convincingly associated with ANA positivity was older age (1.020, 95% CI 1.007, 1.033). Our primary multivariate estimate of the odds ratio (OR) related to ANA positivity was 1.001 (95% CI 1.000, 1.002) for PM2.5 emissions. No clear association was seen with distance to emitters in any of our models, nor with PM2.5 from satellite images, though many of our estimates being relatively imprecise and did not preclude an effect of air pollution on ANA positivity.

Conclusion: In these preliminary analyses, we did not see strong associations of ANA positivity with PM2.5 exposure. We are currently exploring additional models and considering the effects of other air pollution exposures, including nitrogen dioxide (NO2) and ultrafine particles, in a larger sample.

Disclosure: S. Bernatsky, None; A. Smargiassi, None; L. Joseph, None; P. Belisle, None; M. J. Fritzler, Inova Diagnostics, Inc., 5.

To cite this abstract in AMA style:

Bernatsky S, Smargiassi A, Joseph L, Belisle P, Fritzler MJ. Exposure to Fine Particle Air Pollution and Anti-Nuclear Antibodies (ANA) in a Large Population-Based Sample [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/exposure-to-fine-particle-air-pollution-and-anti-nuclear-antibodies-ana-in-a-large-population-based-sample/. Accessed March 21, 2023.

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