ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 643

Ethnicity of Sjögren’s Syndrome

Rohan Sharma1, Astrid Rasmussen2, Lida Radfar3, David M. Lewis4, Kiely Grundahl5, C. Erick Kaufman6, Donald U. Stone7, Joan T. Merrill8, Christopher Lessard9, Kathy L. Sivils9 and Robert Hal Scofield10, 1Medical Service, US Department of Veterans Affaris Medical Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, 4College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 6Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 7Ophthalmology, University of Oklahoam Health Sciences Center; Dean McGee Eye Center, Oklahoma City, OK, 8Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 9Oklahoma Medical Research Foundation, Oklahoma City, OK, 10Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Sunday, November 8, 2015

Title: Sjögren's Syndrome Poster I: Clinical Insights into Sjögren's Syndrome

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

We undertook this study to describe the racial and ethnic diversity of SS compared to that found among patients with SLE.  SLE is known to be more common and severe in Black Americans than White Americans, and related to SS in regard to clinical manifestations and serological findings.

Methods:

Individuals with sicca were evaluated by a rheumatologist, ophthalmologist and a dentist in our Sjögren’s syndrome research clinic. Detailed history and physical examination with stimulated and timed whole unstimulated salivary flow (WUSF) and a lip biopsy along with collection and storage of saliva, ocular surface staining with Lissamine green and fluorescein, an unanaesthetised Schirmer’s test, collection and storage of tears as well as  general laboratory tests were performed. Subjects were classified using ACEG and ACR criteria for primary SS (pSS). We compared the non-Hispanic Black pSS subjects to the non-Hispanic White pSS subjects with one to four age and sex match in terms of clinical manifestations, focus score, WUSF, Schirmer’s, Lissamine green, anti-Ro (or SSA) and anti-La (or SSB) antibody positivity. We also compared the study group with subjects with non-Sjogren’s Sicca (nSS) and those in a SLE cohort followed in the same facility. P values were corrected for multiple comparisons. Due to low representation of other ethnic groups in our study population we only considered non-Hispanic Blacks and non-Hispanic Whites in the study.

Results:

We classified 327 subjects in the clinic as pSS of which 201 were considered for the study. Among these 187 (92.1%) were self-identified as White, while only 14 (6.9%) were self-identified as Black. There were 7 (3.05%) Blacks and 223 (96.95%) whites in nSS group. Among the SLE subjects, there were 106 (29.5%) Black and 253(61.5%) as White. Thus, we found that black Americans were 5 times more likely to have SLE compared to pSS (χ2=36.17, p <0.00001, OR=5.45), while there was no such difference when compared to subjects with nSS (control group)(χ2=2.76,p=0.0966,OR=0.41). We next compared the clinical manifestations found in Black and White subjects with pSS.  Concerning the classification criteria, we found no statistical difference for positive versus negative results.  We also evaluated pSS subjects for systemic manifestations. Black subjects with pSS were found to have higher incidence of hypergamaglobulinemia-IgG type (p=4.98×10-7 by Fisher’s Exact test) than corresponding Whites. There were no statistically significant differences in other extra-glandular clinical or laboratory findings.

Conclusion: In contrast to SLE, where the disease risk and severity are known to be greater in Black Americans as compared to Whites, pSS shows no such predilection.

Disclosure: R. Sharma, None; A. Rasmussen, None; L. Radfar, None; D. M. Lewis, None; K. Grundahl, None; C. E. Kaufman, None; D. U. Stone, None; J. T. Merrill, None; C. Lessard, None; K. L. Sivils, Lilly, 2; R. H. Scofield, Lilly, UCB, 5.

To cite this abstract in AMA style:

Sharma R, Rasmussen A, Radfar L, Lewis DM, Grundahl K, Kaufman CE, Stone DU, Merrill JT, Lessard C, Sivils KL, Scofield RH. Ethnicity of Sjögren’s Syndrome [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/ethnicity-of-sjogrens-syndrome/. Accessed .

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