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Abstracts tagged "ethnic studies and systemic lupus erythematosus (SLE)"

  • Abstract Number: 1088 • ACR/ARHP Annual Meeting 2018

    Pro-Inflammatory and Regulatory Soluble Mediator Pathways Vary between African American and European American SLE Patients

    Samantha Slight-Webb1, Miles C. Smith1, Holden T. Maecker2, Paul J. Utz3, Joel M. Guthridge1 and Judith A. James4, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Stanford University, Stanford, CA, 3Medicine, Stanford University School of Medicine, Stanford, CA, 4Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease that primarily affects women, and is associated with periods of elevated and suppressed clinical symptoms. SLE…
  • Abstract Number: 1823 • ACR/ARHP Annual Meeting 2016

    African American and European American SLE Patients with Variable Disease Activity Reveal Distinct Differences in CD4+ T Cell and Monocyte Pathways

    Samantha Slight-Webb1, Rufei Lu2, Krista M. Bean1, Holden T. Maecker3, Paul J. Utz4, Joel M. Guthridge5 and Judith A. James6, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 4Medicine, Stanford University School of Medicine, Stanford, CA, 5Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder with both genetic and environmental contributions to disease etiology. Patients with different ancestral backgrounds have different…
  • Abstract Number: 643 • ACR/ARHP Annual Meeting 2015

    Ethnicity of Sjögren’s Syndrome

    Rohan Sharma1, Astrid Rasmussen2, Lida Radfar3, David M. Lewis4, Kiely Grundahl5, C. Erick Kaufman6, Donald U. Stone7, Joan T. Merrill8, Christopher Lessard9, Kathy L. Sivils9 and Robert Hal Scofield10, 1Medical Service, US Department of Veterans Affaris Medical Center, Oklahoma City, OK, 2Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, 4College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 6Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, 7Ophthalmology, University of Oklahoam Health Sciences Center; Dean McGee Eye Center, Oklahoma City, OK, 8Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 9Oklahoma Medical Research Foundation, Oklahoma City, OK, 10Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: We undertook this study to describe the racial and ethnic diversity of SS compared to that found among patients with SLE.  SLE is known…
  • Abstract Number: 748 • ACR/ARHP Annual Meeting 2015

    Comparison of Systemic Lupus Erythematosus in 3 Different Asian Ethnic Groups: Results from the 1000 Faces of Lupus Cohort

    Mai Nguyen1, Earl Silverman2, Janet E. Pope3, Paul R. Fortin4, Ann E. Clarke5, Christian Pineau6, Sasha R Bernatsky7, C Douglas Smith8, Gaëlle Chédeville9, Lori B. Tucker10, Michel Zummer11, Marie Hudson6, Adam M. Huber12, Deborah M. Levy13, Hector Arbillaga14, Carol Hitchon15, Christine A. Peschken16 and CaNIOS 1000 Faces Investigators, 1Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Division of Rheumatology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 3University of Western Ontario, London, ON, Canada, 4Medicine, CHU de Québec - Université Laval, Québec, QC, Canada, 5Immunology/Epidemiology, Montreal General Hospital, Montreal, QC, Canada, 6Medicine, McGill University, Montreal, QC, Canada, 7Division of Rheumatolog, McGill Unversity Health Cener, Montreal, QC, Canada, 8The Arthritis Centre, TOH Riverside Campus, Ottawa, ON, Canada, 9Rheumatology, McGill University, Montreal, QC, Canada, 10Rheumatology, BC Children's Hospital, Vancouver, BC, Canada, 11Rheumatology, Hôpital Maisonneuve-Rosemont and University of Montreal, Montreal, QC, Canada, 12Pediatric rheumatology, IWK Health Centre, Halifax, NS, Canada, 13Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 14Calgary Rheumatology, Calgary, AB, Canada, 15University of Manitoba, Winnipeg, MB, Canada, 16Rheumatology, Univ of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Ethnic variations in systemic lupus erythematosus (SLE) are well described, with more prevalent and severe disease in non-Caucasians including North American Asians. However, Asian…
  • Abstract Number: 689 • ACR/ARHP Annual Meeting 2012

    Activation of the Interferon Pathway Is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients

    Kichul Ko1, Yelena Koldobskaya1, Elizabeth Rosenzweig2 and Timothy B. Niewold1, 1Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, 2Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL

    Background/Purpose: Gene expression studies have been instrumental in defining important aspects of the complex immunological pathogenesis in systemic lupus erythematosus (SLE) which is a heterogeneous…

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