ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 589

Erosions at the Sacroiliac Joints and Fatty Lesions at the Spine Are the Most Discriminant Lesions for Recent Onset Axial Spondyloarthritis Recognition

Anna Molto1, Laure Gossec2, Violaine Foltz2, Romain Beaufort3, Jean Denis Laredo4, Pascal Richette5, Philippe Dieude6, Philippe Goupille7, Antoine Feydy8 and Maxime Dougados9, 1Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, 2UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, 3Private Practice,, Paris, France, 4Radiology Department, Lariboisière Hospital, Paris, France, 5Rheumatology Department, Université Paris Diderot, Paris, France, 6Université Paris-Diderot, Paris, France, 7Department of Rheumatology, CHRU de Tours; and Université François-Rabelais de Tours, Tours, France, 8Univ. Paris Descartes, PRES Sorbonne Paris Cité, Service de radiologie B, Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, Paris, France, 9Paris, Paris, France

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Imaging, MRI, performance and spondylarthritis

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 5, 2017

Title: Spondyloarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: only scarce data are available regarding the prevalence of MRI structural lesions of the sacroiliac joints (SIJ) or the spine suggestive of axial Spondyloarthritis (axSpA) in patients with recent onset mechanical chronic back pain (CBP). The aim was to evaluate the prevalence of MRI (SIJ and Spine) structural lesions suggestive of axSpA in a non-axSpA CBP population and to compare its prevalence to an recent onset axSpA cohort.

Methods:

Study design: Observational cross-sectional national multicentre study. Patients: a) Recent onset axSpA patients: first, a sample of 100 patients representative in terms of imaging abnormalities of the global DESIR (1) recent onset axSpA cohort (> 3 months but <3 years), based on the results of the previously published central reading of baseline films of DESIR(2) were selected (e.g. 21% of patients fulfilling the modified NY criteria (mNY)). b) Recent onset CBP patients: consecutive in- and outpatients consulting for recent (>3months but <5years) mechanical CBP, initiating before the age of 45y and with a maximum age of 50y, in four tertiary care Hospitals were included in the study. Imaging: MRI scans (T2-STIR and T1 sequences) of the SIJ and cervico-thoracic and thoraco-lumbar spine were performed in both groups with identical protocol. Central reading: an experienced reader (AM) centrally read all MRI scans, blinded for clinical diagnosis. Statistical analysis: prevalence of lesions and lesions combinations previously proposed(3) to be suggestive of axSpA was compared in both groups. Sensitivity, specificity and positive likelihood ratio (LR+) of each lesion were calculated.

Results:

Results: A total of 98 patients with recent onset CBP were included, and compared to 100 recent onset axSpA patients. Age and gender were comparable (mean (SD) 36.2 (9.9) vs. 32.2 (8.7)y, and 41.8% and 45% males, in the CBP vs. axSpA groups, respectively).Prevalence of chronic lesions of the SIJ was significantly greater in the axSpA group but up to 17% patients with CBP presented at least one chronic lesion of the SIJ (Table). The presence of at least 3 subchondral bone erosions at the SIJ performed the best for axSpA discrimination. Prevalence of chronic lesions of the spine was comparable in the two groups, with high prevalence of fatty lesions across groups; erosions were rare in both groups. The presence of at least 5 fatty lesions was the most discriminant, with a high specificity. Performances of all other structural lesions of the spine were poor.

CBP

N=98

SpA

N=100

p

Se

Spe

LR+

MRI SIJ

N(%) patients with at least one structural lesion

16/95

(16.8%)

24

(24%)

NS

0.2 (0.2, 0.3)

0.8 (0.7,0.0)

1.4 (0.8, 2.5)

N(%) patients with ≥3 subchondral bone erosions

10 /95

(10.5%)

32 (32%)

<0.001

0.32 (0.2, 0.4)

0.9 (0.8, 1.0)

3.0 (1.6, 5.8)

N(%) patients with ≥3 subchondral bone fatty lesions

11/95

(11.6%)

29 (29%)

0.004

0.29 (0.2, 0.4)

0.88 (0.8, 0.9)

2.5 (1.3, 4.7)

N(%) patients with ≥5 subchondral bone erosions or fatty lesions)

13/95

(13.7%)

33 (33%)

0.002

0.33 (0.2, 0.4)

0.9 (0.8, 0.9)

2.4 (1.4, 4.3)

MRI spine

N(%) patients with at least one structural lesion

49 (50.0%)

42/99

(42.4%)

NS

0.4 (0.3, 0.5)

0.5 (0.4, 0.6)

0.8 (0.6, 1.2)

N(%) patients with ≥3 subchondral bone erosions

6 (6.1%)

7/99 (7.1%)

NS

0.1 (0.0, 0.1)

0.9 (0.9, 1.0)

1.2 (0.4, 3.3)

N(%) patients with ≥3 subchondral bone fatty lesions

21(21.4%)

15/99(15.2%)

NS

0.2 (0.1, 0.2)

0.8 (0.7, 0.9)

0.7 (0.4, 1.23

N(%) patients with ≥5 subchondral bone fatty lesions

8 (8.2%)

21/99 (21.2%)

0.02

0.2 (0.1,0.3)

0.9 (0.8, 0.9)

2.5 (1.2, 5.4)

N(%) patients with ≥5 subchondral bone erosions OR fatty lesions

19 (19.4%)

11 /99 (11.1%)

NS

0.1 (0.1, 0.2)

0.8 (0.7, 0.9)

0.6 (0.3, 1.1)

Conclusion: Presence of at least 3 erosions at the MRI-SIJ and at least 5 fatty lesions at the MRI-spine seemed to performed well for axSpA recognition. This suggests that these definitions might be considered (in the future) to be integrated in axSpA classification criteria


Disclosure: A. Molto, None; L. Gossec, None; V. Foltz, None; R. Beaufort, None; J. D. Laredo, None; P. Richette, None; P. Dieude, None; P. Goupille, None; A. Feydy, None; M. Dougados, Abbvie, Pfizer, Eli Lilly and Company, Novartis, UCB, Merck, Roche, BMS UCB, 2,Abbvie, Pfizer, Eli Lilly and Company, Novartis, UCB, Merck, Roche, BMS, UCB, 5.

To cite this abstract in AMA style:

Molto A, Gossec L, Foltz V, Beaufort R, Laredo JD, Richette P, Dieude P, Goupille P, Feydy A, Dougados M. Erosions at the Sacroiliac Joints and Fatty Lesions at the Spine Are the Most Discriminant Lesions for Recent Onset Axial Spondyloarthritis Recognition [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/erosions-at-the-sacroiliac-joints-and-fatty-lesions-at-the-spine-are-the-most-discriminant-lesions-for-recent-onset-axial-spondyloarthritis-recognition/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/erosions-at-the-sacroiliac-joints-and-fatty-lesions-at-the-spine-are-the-most-discriminant-lesions-for-recent-onset-axial-spondyloarthritis-recognition/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology