Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To analyse whether epidemiologic factors (such as gender or age at diagnosis of the disease) are associated with particular disease expressions and define specific epidemiological subsets in patients with sarcoidosis.
Methods: In January 2016, the Autoimmune Diseases Study Group (GEAS-SEMI) created a national registry (SARCOGEAS) of patients with sarcoidosis. Sarcoidosis was diagnosed in agreement with the criteria proposed by the American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG) 1999 statement on sarcoidosis. Organ involvement was retrospectively determined in each patient at the time of diagnosis using the 2014 WASOG organ assessment instrument. Ethnicity was defined according to the FDA classification.
Results: The cohort consisted of 1082 patients (82% biopsy-proven), including 618 (57%) women and 464 (43%) men, with a mean age at diagnosis of 47.2 ± 15.5 years. One hundred forty (13%) patients were born outside Spain. With respect to the FDA ethnic classification, 965 (89%) patients were classified as White, 69 (6%) as Hispanic, 30 (3%) as Black/African American and 18 (2%) as Asian. Thoracic involvement was present at diagnosis in 979 (90%) patients, including 437 (40%) patients presenting with stage I, 374 (35%) with stage II, 123 (11%) with stage III and 26 (2%) presenting with stage IV. According to the WASOG classification, the most frequently reported extrathoracic involvements at diagnosis were cutaneous in 385 (36%) patients, extrathoracic lymph nodes in 218 (20%), liver involvement in 151 (14%) and ocular involvement in 118 (11%).
In the multivariate analysis models, women showed a lower frequency of thoracic involvement (87% vs 93% in men, p=0.019) and a higher frequency of cutaneous (42% vs 26%, p<0.001) and ocular (13% vs 9%, p=0.012) WASOG involvements, patients with a younger disease onset (<35 years) were more frequently born out of Spain (17% vs 11%, p=0.027), had a higher frequency of thoracic disease (94% vs 88%, p=0.008) and a lower frequency of kidney involvement (3% vs 6%, p=0.041), and patients with an elderly onset (age>70 years) were more frequently born in Spain (99% vs 86%, p=0.007) and had a lower frequency of thoracic (81% vs 90%, p=0.006) and cutaneous (23% vs 37%, p=0.001) involvements and a higher frequency of bone marrow involvement (12% vs 4%, p=0.004).
This is one of the largest series of sarcoidosis reported out of the US, predominantly composed by White patients in nearly 90% of cases. Thoracic and extrathoracic involvements at disease presentation were strongly influenced by specific epidemiologic features such as gender, age and ethnicity.
To cite this abstract in AMA style:Retamozo S, Pérez-Alvarez R, Fraile G, Gómez De La Torre R, López Dupla M, De Escalante Yangüela B, Alguacil A, Chara-Cervantes J, Velilla Marco J, Rascón FJ, Garcia Morillo JS, Tolosa C, Fonseca Aizpuru E, Bonet M, Luis Callejas J, De la Red G, Calvo Begueria E, Soler i Ferrer C, Peral Gutiérrez De Ceballos E, Gómez Cerezo JF, Cruz Caparrós G, Perez Guerrero P, Rodríguez Fernández S, Pinilla B, Gato Diez A, Akasbi M, Robles A, Ojeda I, Vives MJ, Morcillo C, Penadés Vidal M, De Vicente M, Kostov B, Ramos-Casals M, Pallarés L, Brito-Zerón P. Epidemiologic Subsets Drive a Differentiated Thoracic and Extrathoracic Presentation of Sarcoidosis: Analysis of 1082 Patients from the Sarcogeas-SEMI Registry [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/epidemiologic-subsets-drive-a-differentiated-thoracic-and-extrathoracic-presentation-of-sarcoidosis-analysis-of-1082-patients-from-the-sarcogeas-semi-registry/. Accessed August 13, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/epidemiologic-subsets-drive-a-differentiated-thoracic-and-extrathoracic-presentation-of-sarcoidosis-analysis-of-1082-patients-from-the-sarcogeas-semi-registry/