ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1350

Elevated Serum Levels of Soluble CD146 and CD146 Autoantibody in Patients with Polymyositis/Dermatomyositis

Eri Watanabe1, Takahisa Gono1,2, Hiroki Yabe1, Masataka Kuwana2, Kazunori Kato3 and Chihiro Terai1, 1Department of Rheumatology, Saitama Medical Center, Jichi Medical University, Saitama, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 3Department of Biomedical Engineering, Faculty of Science and Engineering, Toyo University, Saitama, Japan

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: autoantibodies, biomarkers and polymyositis/dermatomyositis (PM/DM)

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, October 22, 2018

Title: Muscle Biology, Myositis and Myopathies Poster II: Basic and Translational Science

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: CD146 is a transmembrane glycoprotein belong to immunoglobulin superfamily, acts as adhesion molecule for the maintenance of cell monolayer. Human endothelial cells constitutively express CD146 which is involved in angiogenesis and inflammation. Recently, we established a sandwich ELISA for detecting soluble CD146 (sCD146) in human serum and reported presence of elevated level of sCD146 in patients with Behçet’s disease and systemic sclerosis. However, an association of sCD146 with PM/DM remains unknown. The aims of this study are to examine serum levels of sCD146 in patients with PM/DM and their association with clinical features and to clarify the mechanism of the difference in levels of sCD146.

Methods: Serum levels of sCD146 were quantified in 102 patients with PM/DM who visited our hospital from January 2001 to 2017 and compared with those of 22 healthy controls (HC). Recombinant CD146 protein was used to obtain a standard curve to measure quantity of sCD146. We also established another ELISA for detecting autoantibody against CD146 by using human recombinant CD146 protein.

Results: Serum levels of sCD146 were higher in the PM/DM subset than in HC but not statistically significant difference. Especially, the levels of sCD164 was significantly higher (P < 0.01) at mean 12.2 ng/mL in the PM subset, as compared to the DM subset or HC (Figure 1). Inverse correlations were observed between the levels of sCD146 and those of C-reactive protein in the PM/DM subset, and between the levels of sCD146 and those of creatine kinase in the PM subset. The levels of sCD146 were significantly higher (P < 0.05) in the patients with anti-ARS antibody than in patients with anti-TIF1-gamma antibody. There was no correlation between the levels of sCD146 and other clinical features such as complication of interstitial lung disease or malignancy. We hypothesized the existence of CD146 autoantibody in patients with DM and its involvement in the mechanism of the difference in the levels of sCD146. We measured serum CD146 autoantibody by established ELISA and found out the presence of serum CD146 autoantibody in PM/DM and significant high levels (P < 0.05) in the DM subset at 2 folds higher than mean level of the PM subset. These findings suggested the presence of CD146 autoantibodies could make disturbance to detect sCD146 in DM. Additionally, the levels of CD146 autoantibody showed a significant correlation with disease activity in patients with DM.

Conclusion: We identified higher levels of sCD146 in patients with PM than DM, and higher levels of CD146 autoantibody in DM than PM. CD146 could be one of the key factors involved in the pathophysiology of PM/DM.


Disclosure: E. Watanabe, None; T. Gono, Astellas Pharma, 8; H. Yabe, None; M. Kuwana, Astellas, 2,MBL, 7,Astellas, Japan Blood Products Organization, 8; K. Kato, None; C. Terai, None.

To cite this abstract in AMA style:

Watanabe E, Gono T, Yabe H, Kuwana M, Kato K, Terai C. Elevated Serum Levels of Soluble CD146 and CD146 Autoantibody in Patients with Polymyositis/Dermatomyositis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/elevated-serum-levels-of-soluble-cd146-and-cd146-autoantibody-in-patients-with-polymyositis-dermatomyositis/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/elevated-serum-levels-of-soluble-cd146-and-cd146-autoantibody-in-patients-with-polymyositis-dermatomyositis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology