ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2054

Efficacy and Safety Of Low-Intensity Resistance Training Combined With Vascular Occlusion In Polymyositis and Dermatomyositis

Melina Mattar1, Luiz A. Perandini1, Thalita Dassouki2, Samuel K. Shinjo1, Bruno Gualano3, Hamilton Roschel3, Fernanda R. Lima4 and Ana Lucia S. Pinto1, 1University of Sao Paulo, Rheumatology Division, LACRE, Sao Paulo, Brazil, 2Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 3University of Sao Paulo, School of Physical Education and Sport, Sao Paulo, Brazil, 4University of Sao Paulo, Rheumatology Division, Sao Paulo, Brazil

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: , ,

Session Information

Title: Muscle Biology, Myositis and Myopathies: Advances in the Epidemiology, Immunology and Therapy of Myositis

Session Type: Abstract Submissions (ACR)

Background/Purpose: Previous studies have demonstrated that low-intensity resistance training combined with vascular occlusion (VO) improves muscle strength to the magnitude of traditional high-intensity resistance training in healthy subjects. We, therefore, aimed to determine whether low-intensity resistance training combined with VO is safe and effective to improve muscle strength, functional capacity and quality of life in patients with polymyositis (PM) and dermatomyositis (DM).

Methods: Thirteen patients (4 PM and 9 DM according to Bohan and Peter’s criteria, 1975) from the Outpatient Myopathy Unit of our tertiary Center, with complete clinical response to the treatment (age: 45.6±8.8 years; disease duration: 5.4±2.9 years; body mass index (BMI): 31.0±6.6kg/m2; VO2max: 23.3±6.9mL/kg/min) were submitted to a 12-week supervised exercise program that consisted of resistance exercises at low-intensity [30% of one repetition maximum (1RM)] combined with VO (70% of the total occlusion pressure of the tibial posterior artery). Clinical questionnaires [36-item short form health survey (SF-36), the health assessment quality (HAQ) and the visual analogue scale (VAS)], muscle strength (1RM of leg press and leg extension), functional capacity [time stands (TS) and timed up and go (TUG) tests] and serum muscle enzymes were assessed before (PRE) and after (POST) the exercise program. The pharmacological treatment remained unchanged at least three months prior to study entry and throughout the protocol.

Results: Comparison of pre- and post-exercise intervention revealed that all patients had significant improvements in muscle strength (leg-press: 128±62 vs. 155±78kg, P=0.001; leg-extension: 37±10 vs. 46±13kg, P=0.001) and muscle function (TS: 13±2 vs. 15±2, P=0.001; TUG: 6.9±1.1 vs. 6.6±1.0s, P=0.002). Additionally, improvement in quality of life, as measured by the SF-36 (Physical component: 41.6±7.2 vs. 50.0±7.4, P=0.001; Mental component: 42.7±13.0 vs. 56.0±10.1, P = 0.008), HAQ (1.58±1.98 vs. 0.60±0.62, P=0.007) and VAS (VAS patient: 4.6±2.9 vs. 1.6±1.2cm, P=0.024; VAS physician: 2.7±1.2 vs. 1.2±0.6cm, P=0.001). Of note, no change in serum levels of creatine kinase (195±76 vs. 224±171IU/L, P=0.944) and aldolase (3.9±1.5 vs. 3.1±1.6IU/L, P=0.265).

Conclusion: The present work provides novel evidence that a low-intensity resistance training program combined with VO is safe and effective in improving muscle strength, functional capacity, and quality of life in PM and DM patients.

Disclosure:

M. Mattar,
None;

L. A. Perandini,
None;

T. Dassouki,
None;

S. K. Shinjo,
None;

B. Gualano,
None;

H. Roschel,
None;

F. R. Lima,
None;

A. L. S. Pinto,
None.

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