Effects of Coffee Consumption on Serum Uric Acid. a Systematic Review and Meta-Analysis

Jae-Bum Jun¹, Shin-Young Yim², Hyun Jung Kim³, Kyu Yong Park⁴, Hyeong Sik Ahn³, Sun Hee Kim⁴ and Eun Ji Park⁴, ¹Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ²Department of Physical Medicine and Rehabilitation, Ajou University School of Medicine, Suwon, South Korea, ³Department of Preventive Medicine, Korea University College of Medicine, Seoul, South Korea, ⁴Department of Physical Medicine and Rehabilitation, Ajou University Hospital, Suwon, South Korea

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: dietary supplements, gout, meta-analysis and uric acid

Session Information

Date: Tuesday, November 10, 2015

Title: Epidemiology and Public Health Poster III (ACR): Gout and Non-Inflammatory Musculoskeletal Conditions

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Findings on the effect of coffee consumption on serum uric acid has been conflicting. The aim of this systematic review and meta-analysis is to analyze the literature exploring the effect of coffee consumption on serum uric acid.

Methods: We conducted a systematic review to examine the effect of coffee consumption on serum uric acid via meta-analysis. We searched MEDLINE, EMBASE, the Cochrane library, and KoreaMed for all articles published before January 2015. Studies with quantitative data on coffee consumption and serum uric acid level were included. Coffee consumption and serum uric acid level were identified with or without prevalence of gout.

Results: Nine studies were included in the review (published between 1999 and 2014), including a total of 41,217 subjects. Six were from registry and 3 were cross-sectional study. Men showed significantly lower serum uric acid with coffee intake of 1-3 cups/day than coffee intake of <1 cup/day (-0.12 mg/dL [95% CI:-0.17 to 0.08], I² = 41%; p<0.00001). Women showed significantly lower serum uric acid with coffee intake of 4-6 cups/day than coffee intake of <1 cup/day (-0.11 mg/dL [95% CI:-0.20 to -0.02]; p=0.02). Meta-analysis showed that the amount of coffee intake of 1 cup/day or more was significant reduction of the prevalence of gout with negative correlation with the amount of daily coffee for both gender.

Conclusion: The review shows that there is lowering effect of coffee on both serum uric acid and the prevalence of gout for both genders. However, women need more coffee intake for lowering serum uric acid than men do. This is the first systematic review on the effect of coffee consumption on serum uric acid, along with gender difference in the amount of coffee for lowering effect of coffee on serum uric acid. There is a large degree of heterogeneity in the results, and the sources of this need to be investigated.

Disclosure: J. B. Jun, None; S. Y. Yim, None; H. J. Kim, None; K. Y. Park, None; H. S. Ahn, None; S. H. Kim, None; E. J. Park, None.

To cite this abstract in AMA style:

Jun JB, Yim SY, Kim HJ, Park KY, Ahn HS, Kim SH, Park EJ. Effects of Coffee Consumption on Serum Uric Acid. a Systematic Review and Meta-Analysis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/effects-of-coffee-consumption-on-serum-uric-acid-a-systematic-review-and-meta-analysis/. Accessed .

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