Effect of Single 6 Ml Intraarticular Injection of Hylan G-F 20 in Patients with Knee Osteoarthritis: Results of a Single Centre Study

SUNIL KUMAR PANDEY¹ and SAT PAL SINGH², ¹ORTHOPEDIC DEPARTMENT, SAFDARJUNG HOSPITAL, VMMC, NEW DELHI, NEW DELHI, India, ²DEPARTMENT OF MEDICINE, SAFDARJUNG HOSPITAL,VMMC, NEW DELHI, NEW DELHI, India

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Osteoarthritis

Session Information

Date: Tuesday, November 7, 2017

Title: ARHP Osteoarthritis – Clinical Aspects Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: To evaluate the effect of single 6ml intraarticular injection of hylan G-F 20 in patients with knee osteoarthritis.

Author: Dr. Pandey Sunil Kumar*, Dr. Singh Sat Pal*

*Safdarjung hospital, New Delhi

Objective: To evaluate efficacy and effect on analgesic requirement of 6 ml single injection of hylan G-F 20 in patients with primary knee osteoarthritis

Methods: In this prospective study, adult patients with primary knee osteoarthritis (grade II to IV) were treated with 6 ml single intra-articular injection of hylan G-F 20. Patients were followed at 6 and 12 months. Difference in WOMAC score from baseline to 6 and 12 months was evaluated by paired “t” test. Numbers and percentages of patients requiring analgesics on daily basis were recorded at all visits.

Results: A total of 352 patients [male 113 (32.10%); female 239 ((67.90%)] [grade II 197(55.97%), grade III 119 (33.81%) and grade IV 36 (10.23%)] with mean age of 59.10 (4.39) years and mean body mass index 27.20 (3.81) kg/m² were included in the study. Mean weight and height of the study participants was 68.11 (7.40) kg and 159 (10) cm respectively. One hundred patients (28.41%) patients had varus deformity. Twenty five (7.10%) and 14 (3.98%) patients had effusion in the right and left knee respectively. The WOMAC score from reduced from 64.44(16.89) at baseline to 34.00(10.31) at 6 month and 36 (11.65) at 12 months respectively. The difference in the WOMAC score from baseline to 6 months and 12 months was statistically significant (P<0.001 for both). Number of patients requiring analgesics daily reduced from 28(7.95%)at baseline to 2(0.57%) at 6 months and 3(0.85%) at 12 months.

Conclusion: Single 6 ml injection of hylan G-F was effective and well tolerated in patients with knee osteoarthritis. Hylan G-F 20 also reduced the requirement of analgesics.

Key words: Efficacy, hylan G-F 20, knee osteoarthritis

Disclosure: S. K. PANDEY, None; S. P. SINGH, None.

To cite this abstract in AMA style:

PANDEY SK, SINGH SP. Effect of Single 6 Ml Intraarticular Injection of Hylan G-F 20 in Patients with Knee Osteoarthritis: Results of a Single Centre Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/effect-of-single-6-ml-intraarticular-injection-of-hylan-g-f-20-in-patients-with-knee-osteoarthritis-results-of-a-single-centre-study/. Accessed .

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