ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1644

Effect of a Lifestyle Program Based on a Whole Food Plant-based Diet, Physical Activity, and Stress Management in Patients with Metabolic Syndrome-Associated Osteoarthritis: A Randomized Controlled Trial

Wendy Walrabenstein1, Carlijn Wagenaar1, Marike van der Leeden2, Martijn Gerritsen1, Martin van der Esch1 and Dirkjan van Schaardenburg2, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands

Meeting: ACR Convergence 2022

Keywords: diet, health behaviors, Osteoarthritis, physical activity, psychosocial factors

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, November 14, 2022

Title: Abstracts: Osteoarthritis – Clinical

Session Type: Abstract Session

Session Time: 9:00AM-10:30AM

Background/Purpose: Metabolic syndrome with low grade inflammation is associated with chronic diseases including osteoarthritis (OA) (1). A combination of an intensive diet with exercise produced better results in people with osteoarthritis (OA) than either intervention alone (2). We further developed the concept of an integrated lifestyle intervention in people with metabolic syndrome-associated osteoarthritis (MSOA) by combining a whole food plant-based diet (WFPD) with physical activity and stress management and aimed to determine the effect of this program on pain, stiffness, and physical function in patients with MSOA.

Methods: In the “Plants for Joints” (PFJ) parallel-arm, randomized clinical trial, patients with MSOA were assigned to the PFJ group or the control group. Patients with metabolic syndrome (according to NCEP criteria) and OA in the knee and/or hip (according to clinical ACR criteria) were eligible for participation. The PFJ group followed a 16-week lifestyle program based on a WFPD, physical activity, and stress management in addition to usual care. The control group received usual care.

It was hypothesized that the lifestyle program would reduce pain and stiffness and improve physical function, based on the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score (primary outcome). Secondary outcomes included anthropometric and metabolic markers. An intention-to-treat analysis with a linear mixed model, adjusted for baseline values was used to analyze the between-group differences of primary and secondary continuous outcomes.

Results: Of the 92 people screened, 66 were randomized and 64 completed the study (PFJ group: n = 32). Participants were 84% female, had a mean (SD) age of 63 (6) and a mean (SD) BMI of 33 (5) kg/m2. After 16 weeks the PFJ group had a mean 11-point lower (favorable) total WOMAC score (range 0-96) over time (95% CI 6 to 16; p = 0.0001) with significant improvements in all three components pain, stiffness, and physical function compared to the control group (Figure 1). Also, compared to the control group, the PFJ group lost more body weight, fat mass and waist circumference. HbA1c, fasting glucose and LDL improved in the PFJ versus control group, while HDL, triglycerides and blood pressure remained unchanged (Table 1).

Conclusion: The 16-week “Plants for Joints” lifestyle program substantially reduced pain and stiffness and improved physical function in people with metabolic syndrome associated osteoarthritis of hip and/or knee. In addition, following the lifestyle program resulted in improved anthropometric and metabolic outcomes in comparison with usual care.

Reference:

1. Furman et al. 2019, Nat Med.

2. Messier et al. 2013, JAMA

Supporting image 1

Figure 1. Change in Western Ontario and McMaster Universities Arthritis Index (WOMAC) total score (p = 0.0001) and WOMAC component scores for pain (p = 0.04), stiffness (p < 0.001) and function (p = 0.0001) for the Plants for Joints group (n = 32) when compared with the control group (n = 32). Graphs present mean ± standard error.

Supporting image 2

All values for the total group (n = 64), Western Ontario and McMaster Universities Arthritis Index (WOMAC), DEXA = Dual-energy X-ray absorptiometry, SD = standard deviation. Differences in change between group are based on a linear mixed model with random effect for subjects for between group analyses, adjusted for baseline values. Additional adjustment for covariates (sex, age and BMI) did not change outcomes.


Disclosures: W. Walrabenstein, None; C. Wagenaar, None; M. van der Leeden, None; M. Gerritsen, None; M. van der Esch, None; D. van Schaardenburg, None.

To cite this abstract in AMA style:

Walrabenstein W, Wagenaar C, van der Leeden M, Gerritsen M, van der Esch M, van Schaardenburg D. Effect of a Lifestyle Program Based on a Whole Food Plant-based Diet, Physical Activity, and Stress Management in Patients with Metabolic Syndrome-Associated Osteoarthritis: A Randomized Controlled Trial [abstract]. Arthritis Rheumatol. 2022; 74 (suppl 9). https://acrabstracts.org/abstract/effect-of-a-lifestyle-program-based-on-a-whole-food-plant-based-diet-physical-activity-and-stress-management-in-patients-with-metabolic-syndrome-associated-osteoarthritis-a-randomized-controlled-tr/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to ACR Convergence 2022

ACR Meeting Abstracts - https://acrabstracts.org/abstract/effect-of-a-lifestyle-program-based-on-a-whole-food-plant-based-diet-physical-activity-and-stress-management-in-patients-with-metabolic-syndrome-associated-osteoarthritis-a-randomized-controlled-tr/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology