ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1521

Disease Characteristics and Change of Arthritis Activity According to Treatment in Hepatitis B Surface Antigen Positive Rheumatoid Arthritis Patients

Yeonghee Eun1, Hyemin Jeong1, Eun-Jung Park2, Ji Young Chai3, Hyungjin Kim1, Jaejoon Lee1, Eun-Mi Koh1 and Hoon-Suk Cha4, 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Department of Medicine, Division of Rheumatology, Department of Medicine, Jeju National University Hospital, Jeju University School of Medicine, Jeju, South Korea, 3Departement of Internal Medicine, Bundang Jesaeng General Hospital, Seongnam, Korea, The Republic of, 4Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords:

Session Information

Date: Monday, November 14, 2016

Session Title: Rheumatoid Arthritis – Clinical Aspects - Poster II: Co-morbidities and Complications

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:  Rheumatoid arthritis (RA) treatment may differ according to hepatitis B state and consequently bring about different outcome of arthritis. Only a small number of studies have addressed the differences in disease characteristics and treatment patterns of RA in relation to hepatitis B state. However, it has not yet been elucidated whether hepatitis B affects treatment outcome such as disease activity. We investigated possible differences in change of arthritis activity between RA patients according to concomitant hepatitis B virus (HBV) infection.

Methods:  We conducted an age-matched, sex-matched and entry-time-matched cohort study using single center data, from 1 January 2000 to 31 March 2015. Up to three hepatitis B surface antigen (HBsAg)-negative rheumatoid arthritis (RA) patients were matched to each patient with HBsAg-positive RA by age, sex and year of cohort entry. The longitudinal relationship between HBsAg-positivity and RA activity was analyzed using generalized estimating equations in linear regression models. Similar analysis was performed for RA medication use within each group.

Results:   One hundred fifty-two patients were included in the study; 40 were HBsAg-positive. Baseline characteristics did not differ significantly between groups. In regression analysis, RA activity showed time-dependent improvement. The reductions of swollen joint count over time were significantly larger in HBsAg-negative group (b-coefficient 7.91 [95% confidence interval (95% CI) 1.41, 14.41], P = 0.017). However, changes of disease activity score in 28 joints with 3 variables (DAS28-3), tender joint count, erythrocyte sedimentation rate and C-reactive protein level did not differ between groups. There was no difference in alanine aminotransferase level. Over all visits, HBsAg-positive patients were less likely to receive methotrexate (OR 0.09 [95% CI 0.04-0.19], P < 0.0001) and more likely to receive sulfasalazine (OR 3.67 [95% CI 1.94-6.95], P < 0.0001).

Conclusion:  RA medication use was different according to HBsAg-positivity. However, the improvement of RA activity was not significantly affected by concomitant hepatitis B state.

Disclosure: Y. Eun, None; H. Jeong, None; E. J. Park, None; J. Y. Chai, None; H. Kim, None; J. Lee, None; E. M. Koh, None; H. S. Cha, None.

To cite this abstract in AMA style:

Eun Y, Jeong H, Park EJ, Chai JY, Kim H, Lee J, Koh EM, Cha HS. Disease Characteristics and Change of Arthritis Activity According to Treatment in Hepatitis B Surface Antigen Positive Rheumatoid Arthritis Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/disease-characteristics-and-change-of-arthritis-activity-according-to-treatment-in-hepatitis-b-surface-antigen-positive-rheumatoid-arthritis-patients/. Accessed December 10, 2019.

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