Disease Activity, Organ Damage and Patient-Reported Outcome Measures in Swedish Patients with Recent-Onset SLE

Rebecca Heijke¹, Mathilda Björk¹, Martina Frodlund¹, Laura McDonald², Evo Alemao³ and Christopher Sjöwall¹, ¹Linköping University, Linköping, Sweden, ²Bristol-Myers Squibb, Uxbridge, United Kingdom, ³Bristol-Myers Squibb, Princeton, NJ

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Clinical practice, patient-reported outcome measures, prognostic factors and quality of life, SLE

Session Information

Date: Tuesday, October 23, 2018

Title: Systemic Lupus Erythematosus – Clinical Poster III: Treatment

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Patient (pt)-reported outcome measures (PROMs) are important to inform shared decision-making between pts with SLE and physicians.¹ Established measures of disease activity and organ damage are predictors of disease progression, prognosis and survival.^2,3 However, there is no established correlation with PROMs. We used registry data from well-characterized Swedish pts with recent-onset SLE to identify potential correlations of disease activity and organ damage with PROMs. Methods: Consecutive and newly diagnosed pts of the Clinical Lupus Register in Northeast Gothia who met the 1982 ACR⁴ and/or the 2012 Systemic Lupus International Collaborating Clinics (SLICC)⁵ SLE classification criteriawith no prior organ damage were followed prospectively after diagnosis. Pts were seen by a rheumatologist at Months 0 (inclusion), 6, 12, 24, 36, 48 and 60, with collection of SLE Disease Activity Index-2000 (SLEDAI), SLICC/ACR organ damage index score and PROMs (quality of life [QoL]: EuroQoL-5 Dimensions [EQ-5D]; pain and fatigue: visual analog scale [VAS] 0–100 mm) at each visit. The incidence rate (IR) of organ damage and Pearson correlations of SLEDAI and organ damage with PROMs were calculated. Results: Of the 41 pts in the study at baseline: median age 39 years, 80% female, 85% white, 88% met ACR-82 criteria and 37% had lupus nephritis. Organ damage occurred at an overall IR of 13.6 per 100 pt-years (Figure 1), with neuropsychiatric, ocular and cardiovascular damage as most common (Figure 2). SLEDAI significantly correlated with pain at Months 6, 36 and 48 (p<0.03; Figure 3). SLICC/ACR damage index score significantly correlated with EQ-5D (p=0.003) and fatigue (p=0.009) at Month 24.

Conclusion: Our findings illustrate the importance of the interplay between the physician’s and pts’ perception of SLE, which may affect compliance and adherence to therapy, and play a role in achieving successful outcomes in SLE management.

References

1. Vollenhoven RF, et al. Ann Rheum Dis 2014.

2. Nived O, et al. J Rheumatol 2002.

3. Chambers SA, et al. Rheumatology (Oxford) 2009.

4. Tan EM, et al. Arthritis Rheum 1982.

5. Petri M, et al. Arthritis Rheum 2012. We thank Sreeram Ramagopalan for assistance with this study. Medical writing assistance was provided by Bu Reinen, PhD, at Caudex and was funded by Bristol-Myers Squibb.

Disclosure: R. Heijke, None; M. Björk, None; M. Frodlund, None; L. McDonald, Bristol-Myers Squibb, 3; E. Alemao, Bristol-Myers Squibb, 1, 3; C. Sjöwall, None.

To cite this abstract in AMA style:

Heijke R, Björk M, Frodlund M, McDonald L, Alemao E, Sjöwall C. Disease Activity, Organ Damage and Patient-Reported Outcome Measures in Swedish Patients with Recent-Onset SLE [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/disease-activity-organ-damage-and-patient-reported-outcome-measures-in-swedish-patients-with-recent-onset-sle/. Accessed .

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