Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Dickkopf-1 (DKK1) is a natural inhibitor of Wnt signaling pathway that could be involved in promoting osteoclastogenesis through suppression of osteoprotegerin (1,2). Systemic sclerosis (SSc) patients present an increased risk of low bone mass and of osteoporosis (OP) as a result of different causes (3,4). The aim of this study is to investigate in different nailfold videocapillaroscopic (NVC) patterns (“Early”, “Active”, and “Late”) in SSc patients and to evaluate possible correlations between DKK-1 levels and Trabecular Bone Score (TBS), finally to compare the results with healthy subjects (CNT).
60 SSc patients and 60 CNT were enrolled. Dkk-1 serum levels were measured in all 120 subjects by ELISA methods (Quantikine Human DKK-1 Immunoassay R&D System, Minneapolis, USA). Nailfold videocapillaroscopic (NVC) and TBS analysis and Bone Mineral Density (BMD, g/cm2) were also performed.
DKK-1 levels were statistically significantly higher in SSc patients with “Late” NVC pattern than in those both “Active” and “Early” (p<0.0001) and its levels were correlated with Trabecular Bone Score only in patients with “Late” NVC pattern (p=0.001). Serum DKK-1 levels were significantly higher in patients with SSc than in CNT (p <0.007). A negative correlation between Raynaud’s phenomenon duration (years expressed) and DKK-1 levels (p<0.01) was also observed.
Dickkopf-1 values is increased in SSc patients with “Late” nailfold capillaroscopy pattern than in both “Active” and “Early” pattern and in SSc patients than in CNT, furthermore its level correlates with TBS in “Late” NVC pattern.
1.Krishnan V et al. J Clin Invest 2006; 116: 1202-9 2. Roux JP et al. Osteoporosis Int 2013; 24:2455-60. 3. Cutolo M,et al. J Rheumatol. 2000;27:155-60. 4. Ruaro B, et al. Rheumatology 2018 [Epub ahead of print].
To cite this abstract in AMA style:Ruaro B, Casabella A, Paolino S, Pizzorni C, Smith V, Seriolo C, Molfetta L, Odetti P, Cutolo M. Dickkopf-1 Serum Levels in Patients with Systemic Sclerosis and Correlation with Trabecular Bone Score [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/dickkopf-1-serum-levels-in-patients-with-systemic-sclerosis-and-correlation-with-trabecular-bone-score/. Accessed June 4, 2020.
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