Dickkopf-1 Serum Levels in Patients with Systemic Sclerosis and Correlation with Trabecular Bone Score

Barbara Ruaro¹, Andrea Casabella², Sabrina Paolino¹, Carmen Pizzorni², Vanessa Smith³, Chiara Seriolo⁴, Luigi Molfetta⁴, Patrizio Odetti⁴ and Maurizio Cutolo², ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ³Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁴Centro di Ricerca su Osteoporosi e Patologie Osteoarticolari CROPO, Di.M.I., Genoa, Italy, Genoa, Italy

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Connective tissue diseases, imaging techniques, laboratory tests, osteoporosis and systemic sclerosis

Session Information

Date: Tuesday, October 23, 2018

Session Title: Osteoporosis and Metabolic Bone Disease – Basic and Clinical Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Dickkopf-1 (DKK1) is a natural inhibitor of Wnt signaling pathway that could be involved in promoting osteoclastogenesis through suppression of osteoprotegerin (1,2). Systemic sclerosis (SSc) patients present an increased risk of low bone mass and of osteoporosis (OP) as a result of different causes (3,4). The aim of this study is to investigate in different nailfold videocapillaroscopic (NVC) patterns (“Early”, “Active”, and “Late”) in SSc patients and to evaluate possible correlations between DKK-1 levels and Trabecular Bone Score (TBS), finally to compare the results with healthy subjects (CNT).

Methods:

60 SSc patients and 60 CNT were enrolled. Dkk-1 serum levels were measured in all 120 subjects by ELISA methods (Quantikine Human DKK-1 Immunoassay R&D System, Minneapolis, USA). Nailfold videocapillaroscopic (NVC) and TBS analysis and Bone Mineral Density (BMD, g/cm²) were also performed.

Results:

DKK-1 levels were statistically significantly higher in SSc patients with “Late” NVC pattern than in those both “Active” and “Early” (p<0.0001) and its levels were correlated with Trabecular Bone Score only in patients with “Late” NVC pattern (p=0.001). Serum DKK-1 levels were significantly higher in patients with SSc than in CNT (p <0.007). A negative correlation between Raynaud’s phenomenon duration (years expressed) and DKK-1 levels (p<0.01) was also observed.

Conclusion:

Dickkopf-1 values is increased in SSc patients with “Late” nailfold capillaroscopy pattern than in both “Active” and “Early” pattern and in SSc patients than in CNT, furthermore its level correlates with TBS in “Late” NVC pattern.

References:

1.Krishnan V et al. J Clin Invest 2006; 116: 1202-9 2. Roux JP et al. Osteoporosis Int 2013; 24:2455-60. 3. Cutolo M,et al. J Rheumatol. 2000;27:155-60. 4. Ruaro B, et al. Rheumatology 2018 [Epub ahead of print].

Disclosure: B. Ruaro, None; A. Casabella, None; S. Paolino, None; C. Pizzorni, None; V. Smith, None; C. Seriolo, None; L. Molfetta, None; P. Odetti, None; M. Cutolo, None.

To cite this abstract in AMA style:

Ruaro B, Casabella A, Paolino S, Pizzorni C, Smith V, Seriolo C, Molfetta L, Odetti P, Cutolo M. Dickkopf-1 Serum Levels in Patients with Systemic Sclerosis and Correlation with Trabecular Bone Score [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/dickkopf-1-serum-levels-in-patients-with-systemic-sclerosis-and-correlation-with-trabecular-bone-score/. Accessed June 4, 2020.

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