Session Information
Date: Monday, October 22, 2018
Session Title: Sjögren's Syndrome – Basic and Clinical Science Poster
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose:Labial salivary gland biopsy (LSGB) is a safe and minimally invasive procedure used in the diagnostic evaluation of Sjogren’s Syndrome (SS). The objectives of this study are: to describe the demographic, clinical and histological characteristics of patients submitted for LSGB; to examine the usefulness of this procedure as a diagnostic tool for SS; to assess the association between histological findings and antibodies.
Methods: An observational, analytical, cross-sectional study was performed between June 1996 and July 2017. Patients with SS were classified according the AECG-2002 and ACR-2012 criteria. Grades III and IV biopsy of the Chisholm and Mason´s classification/focus score ≥1 were considered positive. Data was analyzed using the statistical package SPSS 21.
Results: 1101 patients were included, 91 % females. The mean age was 52 ± years(range18–86). SS was diagnosed in 413 (37.5%) patients. 34% of the biopsies were positive. Table 1 shows the clinical characteristics and complementary studies in patients with nonspecific dryness syndrome (No-SS) and SS. In bivariate analysis there was an association between antiRo, ANA and RF antibodies and LSGB. In multivariate analysis the significance for anti-Ro (OR: 6.33; 95% CI 3.22 to 12.15), ANA (OR: 3.26; 95% CI 2.15 to 4.94) and RF (OR: 3.05; 95% CI 2.04 to 4.56) was maintained.
|
Parameters |
SS n (%) |
No-SS n (%) |
p |
OR |
|
Female |
380/413 (92) |
619/688 (90%) |
0.284 |
1.284 (0.832-1.981) |
|
Xerostomia |
351/410 (85.6) |
518/679 (76.3) |
<0.001 |
1.85 (1.33-2.57) |
|
Xerophthalmia |
368/409 (90) |
559/679 (82.3) |
0.001 |
1.93 (1.32-2.81) |
|
Parotidomegaly |
90/404 (22.3) |
58/673 (8.6) |
<0.001 |
3.04 (2.13-4.34) |
|
Abnormal ophtalmic test |
260/277 (93.9) |
237/355 (66.9) |
<0.001 |
7.62 (4.45-13.04) |
|
Abnormal salivary test |
66/76 (86.8) |
84/115 (73) |
0.03 |
2.44 (1.11-5.33) |
|
antiRo/SS-A antiLa/SS-B ANA RF |
120/366 (32.8) 49/366 (13.4) 194/387 (50.1) 176/394 (44.7) |
18/558 (3.2) 3/557 (0.5) 82/606 (13.5) 115/618 (18.6) |
<0.001 <0.001 <0.001 <0.001 |
14.63 (8.72-24.56) 28.55 (8.83-92.33) 6.42 (4.73-8.73) 3.53 (2.66-4.69) |
|
LSGB G III |
143/413 (34.6) |
0/687 (0) |
<0.001 |
3.54 (3.2-3.9) |
|
LSGB G IV |
227/413 (55) |
0/687 (0) |
<0.001 |
4.69 (4.13-5.33) |
|
Parameters |
Sensitivity |
Specificity |
PPV |
NPV |
LR |
|
Ro/SS-A* |
32.8 |
96.8 |
86.9 |
68.7 |
8 |
|
La/SS-B* |
13.4 |
99.5 |
94.2 |
63.6 |
13 |
|
ANA* |
50.1 |
86.5 |
70.2 |
73.1 |
3.57 |
|
RF* |
44.7 |
81.4 |
60.4 |
69.7 |
2.3 |
Conclusion: LSGB is a simple, safe, and useful tool for the diagnosis of Sjögren’s syndrome. It exhibits an adequate balance between sensitivity, specificity, positive and negative predictive value. Antibodies showed a significant association with a positive LSGB with low sensitivity for SS screening but high specificity. LSGB has a great value in “seronegatives patients”.
To cite this abstract in AMA style:
Flores J, Baenas D, Haye Salinas MJ, Retamozo S, Pirola JP, Benzaquén N, Riscanevo N, Ceballos MF, Alvarez AC, Saurit V, Alvarellos A, Serravalle P, Ortiz A, Paira S, Caeiro F. Diagnostic Performance of Labial Salivary Gland Biosy, Serological and Clinical Data in Sjogrens Syndrome. in Argentinian Multicenter [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/diagnostic-performance-of-labial-salivary-gland-biosy-serological-and-clinical-data-in-sjogrens-syndrome-in-argentinian-multicenter/. Accessed March 21, 2023.« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/diagnostic-performance-of-labial-salivary-gland-biosy-serological-and-clinical-data-in-sjogrens-syndrome-in-argentinian-multicenter/