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Abstract Number: 638

Diagnostic Delay and Associated Factors in Axial Spondyloarthritis across Europe. Results from the European Map of Axial Spondyloarthritis Survey

Laure Gossec1, Marco Garrido-Cumbrera2,3,4, Denis Poddubnyy5,6, David Galvez-Ruiz2,4, Christine Bundy7, Carlos Jesus Delgado Dominguez2,4, Raj Mahapatra8, Pedro Plazuelo-Ramos3, Souzi Makri9 and Victoria Navarro-Compán10, 1Sorbonne Universités, Paris, France, 2Health & Territory Research (HTR), Seville, Spain, 3Spanish Coordinator of Spondyloarthritis Associations (CEADE), Madrid, Spain, 4Universidad de Sevilla, Seville, Spain, 5German Rheumatism Research Centre, Berlin, Germany, 6Charité Universitätsmeidzin Berlin, Berlin, Germany, 7Cardiff University, Cardiff, United Kingdom, 8Ankylosing Spondylitis International Federation (ASIF), London, United Kingdom, 9Cyprus League Against Rheumatism, Nicosia, Cyprus, 10Immuno-Rheumatology research group, IdiPaz. La Paz University Hospital, Madrid, Spain

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: cross-sectional studies, diagnosis and spondylarthritis

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Session Information

Date: Sunday, October 21, 2018

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Imaging, Clinical Studies, and Treatment

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Axial Spondyloarthritis (axSpA) is a chronic inflammatory disease associated with a long diagnostic delay (DD); however, recent data suggests improvements1. The purpose was to assess the evolution of DD over time as reported by European axSpA patients and to identify factors associated with DD.

 

Methods: Between July 2017 and February 2018, 2846 axSpA patients participated in the European Map of Axial Spondyloarthritis (EMAS) survey across 13 countries. DD was patient-reported and defined as the time between symptom onset and formal diagnosis. Socio-demographics (gender, country, education, and relationship status), disease characteristics (report of extra-articular manifestations, HLA-B27 positive and axSpA subtype) and year of onset were assessed using bivariate Mann-Whitney and Kruskall-Wallis homogeneity tests and Pearson correlation coefficient. Moreover, a stepwise forward linear regression was conducted using variables that were significantly associated with DD.

 

Results: Of the 2846 patients, 61.4% were female. The mean age was 43.9 (SD 12.3) years. 85.5% self-reported having AS (n=2394/2800), 73.9% were HLA-B27 positive (n=1282/1735), and 50.7% had received biologic treatment (n=953/1880). The mean DD was 7.4 (SD 8.4) years with a median of 4.0 years. The bivariate analysis showed that DD was associated with the female gender, participant’s country and year of onset but not associated with educational level, relationship status or disease characteristics (Table 1). Stepwise forward regression also showed that all the variables with bivariate association had significant explanatory power over DD. There was a significant correlation between year of onset and DD; the more recent the disease onset, the shorter the DD (Pearson correlation -0.55; p<0.001) (Figure 1).

 

Conclusion: Despite recent progress in the field of axSpA, DD remains high in Europe (7.4 years). However, EMAS results show that DD is decreasing over time. The strongest factors associated with a longer DD were in order: female gender, country and earlier year of onset. Increased understanding of the factors associated with DD is needed to support earlier diagnosis.

 

1.       Sørensen et al. Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: results from the Danish nationwide DANBIO registry. Annals of the Rheumatic Diseases 2015;74:e12.

 

 

 

 

 

 

 

 

 

 

 

Table 1. Diagnostic delay by patient characteristics and significance in bivariate and multivariable analyses

Variable

Mean (SD) DD if YES

Mean (SD) DD if NO

P-value

Bivariate

Beta (95% CI) multivariable

Gender, Male

6.1 (7.4)

8.2 (8.9)

<.0001

2.53 (1.87-3.19)

Relation status,  In relationship

7.5 (8.5)

7.2 (8.1)

.876

NA

Country

NA

NA

<.0001

.219 (0.12-0.32)

Year of onset

7.44

<.0001

 .001 (0.000-0.002)

Subtype, AS vs other

7.3 (8.2)

7.8 (9.4) to 8.3 (9.6)

.760

NA

HLA B27+

8.3 (8.3)

9.0 (9.3)

.775

NA

Extra-articular manifestations, Uveitis

8.0 (8.3)

7.6 (8.4)

.098

NA

Extra-articular manifestations, Crohn’s disease

7.7 (8.7)

7.5 (8.4)

.786

NA

Extra-articular manifestations: Psoriasis

7.2 (8.8)

6.1 (7.6)

.239

NA

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Figure 1. Scatter diagram for year of disease onset and diagnostic delay (N: 2,652)


Disclosure: L. Gossec, None; M. Garrido-Cumbrera, None; D. Poddubnyy, None; D. Galvez-Ruiz, None; C. Bundy, None; C. J. Delgado Dominguez, None; R. Mahapatra, None; P. Plazuelo-Ramos, None; S. Makri, None; V. Navarro-Compán, None.

To cite this abstract in AMA style:

Gossec L, Garrido-Cumbrera M, Poddubnyy D, Galvez-Ruiz D, Bundy C, Delgado Dominguez CJ, Mahapatra R, Plazuelo-Ramos P, Makri S, Navarro-Compán V. Diagnostic Delay and Associated Factors in Axial Spondyloarthritis across Europe. Results from the European Map of Axial Spondyloarthritis Survey [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/diagnostic-delay-and-associated-factors-in-axial-spondyloarthritis-across-europe-results-from-the-european-map-of-axial-spondyloarthritis-survey/. Accessed May 17, 2022.
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