Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with frequent involvement of the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. Despite the fact that depression is prevalent in SLE, its importance and impact may be underestimated. There are previous reports from Asia and North America about the association of depression with poor Health-Related Quality of Life (HRQoL) in SLE patients. However, there are few reports about this matter from Latin-American patients. The aim of the study was to evaluate whether depression is associated with poor HRQoL in Latin-American SLE patients.
Methods: In a cross-sectional single center study, we evaluated 94 SLE patients, who were seen in our Rheumatology Department between March 2015 and June 2016. SLE was defined by the 1997 revised and updated ACR criteria. Demographic and clinical data were obtained from interview, physical exam and chart review. Disease activity was ascertained with the systemic lupus erythematosus disease activity index (SLEDAI), and disease damage was ascertained with the SLICC/ACR damage index (SDI). Depression was measured with the Beck’s test, which determined its severity varying from minimal (0-13) to severe (29-63) and HRQoL with the SF-36. Univariable and multivariable linear regression models were performed in order to evaluate the association between depression and HRQoL Multivariable analyses were adjusted for age, disease duration, socioeconomic status, SLEDAI, SDI, use of prednisone, antimalarials and immunosuppressive drugs.
Results: Ninety-four SLE patients with a mean age of 45.50 (SD: 12.24) years. Almost all of them were mestizo, only one was African Latin-American. The mean SLEDAI was 4.97 (SD 4.15), the mean SDI was 0.91 (SD 1.21), the mean physical component of the SF36 was 46.43 (SD 18.97) and the mean mental component of the SF36 was 48.65 (SD: 17.71), mean Beck’s test was 6.44 (SD 7.25). Univariable and multivariable associations between Beck’s test and components of SF-36 are depicted in Table 1. Table1: Association of depression with HRQoL
|B (95% CI)||p value||B (95% CI)||p value|
|Physical Component Score||-1.07 (-1.55; -0.59)||<0.001||-1.02 (-1.47; -0.57)||<0.001|
|Mental Component Score||-1.12 (-1.56; -0.68)||<0.001||-1.14 (-1.54; -0.74)||<0.001|
|Physical Functioning||-1.24 (-1.87;-0.61)||<0.001||-1.18 (-1.72; -0.63)||<0.001|
|Physical Role||-1.14 (-2.2; -0.02)||0.046||-1.04(-2.09; -0.004)||0.049|
|General health||-0.84 (-1.3; -0.37)||<0.001||-0.84 (-1.28; -0.40)||<0.001|
|Bodily pain||-1.12 (-1.71; -0.53)||<0.001||-1.02 (-1.59; -0.44)||<0.001|
|Vitality||-0.94 (-1.37; -0.51)||<0.001||-0.96 (-1.38; -0.55)||<0.001|
|Social Role||-1,36 (-1.9; -0.80)||<0.001||-1.42 (-1.96; -0.88)||<0.001|
|Emotional Role||-1.53 (-2.6; -0.43)||0.006||-1.50 (0.50; -2.49)||0.003|
|Mental Health||-0.88 (-1.34; -0.42)||<0.001||-0.92 (-1.37; -0.48)||<0.001|
CI: Confidence Interval*Adjusted by age, disease duration, socioeconomic status, SLEDAI, SDI, use of prednisone, antimalarials and immunosuppressive drugs.
Conclusion: In SLE patients, the presence of depression is associated with a worse HRQoL, independently of other risk factors.
To cite this abstract in AMA style:Velarde-Mejia YC, Ugarte-Gil M, Gamboa-Cardenas RV, Zevallos F, Medina M, Cucho-Venegas JM, Alfaro J, Rodriguez-Bellido Z, Pastor-Asurza CA, Perich-Campos R. Depression Is Associated with a Poorer with Health-Related Quality of Life in Patients with Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/depression-is-associated-with-a-poorer-with-health-related-quality-of-life-in-patients-with-systemic-lupus-erythematosus/. Accessed August 4, 2021.
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