ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 3237

Decreased Cardiovascular Mortality in Patients with Incident Rheumatoid Arthritis (RA) in Recent Years: Dawn of a New Era in Cardiovascular Disease in RA?

Elena Myasoedova1, Cynthia S. Crowson2, Eric L. Matteson3, John M. Davis III4, Terry M. Therneau5 and Sherine E. Gabriel6, 1Internal Medicine and Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Division of Rheumatology, Mayo Clinic, Rochester, MN, 5Department of Health Sciences Research, Mayo Clinic, Rochester, MN, 6Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Cardiovascular disease, morbidity and mortality and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Session Information

Date: Wednesday, November 11, 2015

Session Title: Rheumatoid Arthritis - Clinical Aspects VI: Death Be Not Proud-Mortality and Treatment Outcomes in RA (Includes 2014 Lee C. Howley, Sr. Prize for Arthritis Research Introductory Talk)

Session Type: ACR Concurrent Abstract Session

Session Time: 9:00AM-10:30AM

Background/Purpose:
Rheumatoid
arthritis (RA) is associated with increased cardiovascular (CV) morbidity and mortality
as compared to the general population. Recent prospective studies with limited
follow-up suggest a trend towards decreasing CV fatality in RA. Longitudinal
studies of CV mortality trends in RA patients diagnosed in the recent years are
lacking, and the trends in the relative CV mortality in RA versus the general population
are not fully understood. We aimed to assess trends in
CV mortality in patients with incident RA in 2000-2007 compared to the previous
decades, and to evaluate trends in relative CV mortality in RA compared to
non-RA subjects.

Methods: The
study population comprised a retrospectively identified population-based
incidence cohort of patients with RA (age≥18 years, 1987 ACR criteria
met in 1980-2007). A comparison cohort included non-RA subjects from the same
underlying population with similar age, sex and calendar year of index. All
subjects were followed until death, migration, or Jan. 1, 2014. Underlying
causes of death were obtained from state and local death certificates as well
as the National Death Index Plus and grouped according to ICD-9 and ICD-10
chapters. Kaplan-Meier methods were used to estimate CV mortality
rates. Cox
proportional hazards models, adjusting for age and sex, were used to compare CV
mortality by decade.

Results: The
study included a total of 813 RA patients (mean age 55.9
years; 68% female; 66% rheumatoid factor [RF] positive) and 813 non-RA subjects
(mean
age
55.9 years; 68% female). Figure shows CV mortality by decade of RA
incidence/index date and the table summarizes these data. In patients
with incident RA during the 2000–2007 period, the 10-year overall CV mortality
was 2.8% (95% confidence interval [CI]: 0.4%, 5.2%); coronary heart disease (CHD)
mortality was 1.2% (95% CI: 1.0, 1.4%), suggesting significant improvement compared
to those diagnosed in 1990–1999  (hazard ratio [HR] for overall CV death: 0.43;
95% CI: 0.19, 0.94; p=0.035; CHD death: HR 0.21; 95% CI: 0.05, 0.95; p=0.042). Furthermore,
10-year overall CV mortality and CHD mortality in 2000-2007 RA incidence cohort
did not differ from non-RA subjects (p=0.95 and p=0.79, respectively), which
has not been observed in RA patients diagnosed in the prior decades.

Conclusion:
Our
findings suggest significant improvement in overall CV mortality, particularly CHD
mortality, among patients with incident RA in 2000-2007 versus patients with incident
RA in the previous decades. Furthermore, we have shown significant improvement
in the relative 10-year CV mortality, including CHD mortality, in patients with
incident RA in 2000-2007 versus the general population. These findings represent
an important milestone in CV disease management in RA with significant implications
for understanding determinants of improvement of CV disease in RA and in the
general population.


Disclosure: E. Myasoedova, None; C. S. Crowson, None; E. L. Matteson, None; J. M. Davis III, None; T. M. Therneau, None; S. E. Gabriel, None.

To cite this abstract in AMA style:

Myasoedova E, Crowson CS, Matteson EL, Davis JM III, Therneau TM, Gabriel SE. Decreased Cardiovascular Mortality in Patients with Incident Rheumatoid Arthritis (RA) in Recent Years: Dawn of a New Era in Cardiovascular Disease in RA? [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/decreased-cardiovascular-mortality-in-patients-with-incident-rheumatoid-arthritis-ra-in-recent-years-dawn-of-a-new-era-in-cardiovascular-disease-in-ra/. Accessed June 25, 2022.
  • Tweet
  • Email
  • Print

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/decreased-cardiovascular-mortality-in-patients-with-incident-rheumatoid-arthritis-ra-in-recent-years-dawn-of-a-new-era-in-cardiovascular-disease-in-ra/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2022 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies