Cortical Bone Changes in Pre- and Postmenopausal Healthy Women Measured with HR-pQCT

Jackeline Couto Alvarenga¹ and Rosa M R Pereira², ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Bone, HR-pQCT, menopause and women's health

Session Information

Date: Sunday, November 13, 2016

Title: Osteoporosis and Metabolic Bone Disease – Clinical Aspects and Pathogenesis - Poster

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Increased fracture rates are well-recognized in adults with trabecular and cortical bone deficits, but cortical evaluation has been poorly studied. The aim of this study is to analyze the cortical bone parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT, Scanco Medical AG, Switzerland) parameters in a cohort of 450 healthy women and compare these cortical parameters in pre- and postmenopausal.

Methods: The distal radius (DR) and distal tibia (DT) of 228 premenopausal women and 222 postmenopausal women were scanned using HR-pQCT. The entire volume of interest (VOI) was automatically separated into cortical and trabecular regions using a threshold-based algorithm and the following cortical parameters were obtained: cortical volumetric bone mineral density (Ct.vBMD), cortical thickness (Ct.Th). Moreover, cortical porosity (Ct.Po) was calculated as the percentage of void space in the cortex. Stiffness was analysed with a software specific finite element analysis (Scanco Medical AG, Switzerland). Significance was accepted at p < 0.05.

Results: At distal radius, the density (Ct.vBMD) and thickness (Ct.Th) showed an important decrease of these parameters up to 10 years after menopause, and remained stable after this period. Differently, Ct.Po showed a continue alterations (increase) linearly with age. Regarding distal tibia site, the deterioration of the Ct.vBMD, Ct.Th and Ct.Po were observed linearly with aging. The Pearson correlation demonstrated that density and thickness cortical parameters at DR and DT showed a moderate significant correlation (Ct.vBMD: DR: r= 0.521, DT: r=0.316; Ct.Th: DR: r= 0.619, DT: r= 0.392, p<0.01) and a weak correlation with cortical porosity (Ct.Po- DR: r= -0.162, DT: r= -0.273 (p<0.01) with stiffness parameter.

Conclusion: Our results showed that cortical parameters of the distal radius have a different behavior during aging comparing to distal tibia site. Moreover, cortical density/thickness showed better correlation with strength parameter, suggesting that density/thickness parameter are better for predicting cortical bone quality comparing to cortical porosity.

Disclosure: J. C. Alvarenga, None; R. M. R. Pereira, None.

To cite this abstract in AMA style:

Alvarenga JC, Pereira RMR. Cortical Bone Changes in Pre- and Postmenopausal Healthy Women Measured with HR-pQCT [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/cortical-bone-changes-in-pre-and-postmenopausal-healthy-women-measured-with-hr-pqct/. Accessed .

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/cortical-bone-changes-in-pre-and-postmenopausal-healthy-women-measured-with-hr-pqct/