ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016 ACR/ARHP Annual Meeting
    • 2015 ACR/ARHP Annual Meeting
    • 2014 ACR/ARHP Annual Meeting
    • 2013 ACR/ARHP Annual Meeting
    • 2012 ACR/ARHP Annual Meeting
    • 2011 ACR/ARHP Annual Meeting
    • 2010 ACR/ARHP Annual Meeting
    • 2009 ACR/ARHP Annual Meeting
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 665

Construct Validity of Disease Activity for Psoriatic Arthritis Composite Index and Tentative Cut-Off Values in a Cohort of Patients with Psoriatic Arthritis

Josefina Gallino Yanzi1, Emilce Schneeberger1, Osvaldo Luis Cerda1, Cecilia Zaffarana1, Margarita Landi1, Marcos G. Rosemffet2, Natalia Zamora3, Tomas Cazenave2, Fernando Dal Pra1, Paula Kohan4, Emilio Buschiazzo5 and Gustavo Citera2, 1Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 2Rheumatology, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 3Reumatologia, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 4Hospital Dr. E. Tornu, Buenos Aires, Argentina, 5Rheumatology, Hospital Sr Del Milagro, Salta, Argentina

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Psoriatic arthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 8, 2015

Session Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment Poster I: Clinical Aspects and Assessments

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Disease Activity for Psoriatic Arthritis (DAPSA) is a composite index that assesses disease activity in patients with Psoriatic Arthritis (PsA) taking into account peripheral arthritis. The aim of our study was to validate DAPSA and to evaluate its performance using minimal disease activity (MDA) and different cut-off points.

Methods: Patients ≥18 years with PsA according to CASPAR criteria, belonging to RAPSODIA cohort were included. We recorded demographic data, clinical presentation, comorbidities and treatment. Morning stiffness, pain and global activity by patient and physician were assessed using visual analogue scale (VAS). We evaluated tender (68) and swollen joints (66), dactylitis and enthesitis by MASES (Maastricht Ankylosing Spondylitis Enthesitis Score). CRP and ESR were measured. ASQoL (Ankylosing Spondylitis Quality of Life), PsAQoL (Psoriatic Arthritis Quality of Life), HAQ (Health Assessment Questionnaire,) BASFI and BASDI were completed. DAS28 (Disease Activity Score), DAPSA, SDAI (Simplified Disease Activity Index), CDAI (Clinical Disease Activity Index), and CPDAI (Composite Psoriatic Disease Activity Index) were calculated. Hypothetical cases of patients with PsA with data necessary to calculate DAPSA were assessed by 10 rheumatologists trained in the evaluation of patients with PsA. They had to consign if the patient was in remission, low, moderate or high disease activity. Statistical analysis: Student T test and ANOVA for continuous variables and Chi2 test and Fisher’s exact test for categorical variables. Spearman Rho, and ROC curves for cut-off points.

Results: We included 112 patients, 57 males (50.9%), with a median age of 54 years (IQR 42-63) and median disease duration of 9 years (IQR 5-15). DAPSA had excellent correlation with DAS28 (Rho:0.85), CDAI (Rho:0.95), SDAI (Rho:0.94) and tender joint count (Rho:0.84), and good with BASDI (Rho:0.68), CPDAI (Rho:0.58), ASQoL (Rho:0.63), PsAQoL (Rho:0.51), BASFI (Rho:0.58), HAQ (Rho:0.59), swollen joint count (Rho:0.69), pain (Rho:0.79) and patient´s global activity (Rho:0.72).  Patients who achieved MDA were significantly discriminated by DAPSA (mean 4.9±4.21 vs 20.6±12.5) as well as by the other composite indexes. Using established cut-off values of SDAI for Rheumatoid Arthritis (RA) and experts opinion we performed ROC curves for different cut-off values for DAPSA. Based on these values, a DAPSA score ≤ 5.3 was considered remission, 5.4 to 14.8 low disease activity, 14.9 to 37.7 moderate disease activity and ≥ 37.8 high disease activity. These cut-off values had a sensitivity and specificity ≥ 90%, with an area under the curve of 98%.

Conclusion: DAPSA is a valid and easy to calculate index for peripheral joint activity in PsA patients. It can perfectly discriminate patients in MDA and we proposed possible cut-off values for different disease activity states.


Disclosure: J. Gallino Yanzi, None; E. Schneeberger, None; O. L. Cerda, None; C. Zaffarana, None; M. Landi, None; M. G. Rosemffet, None; N. Zamora, None; T. Cazenave, None; F. Dal Pra, None; P. Kohan, None; E. Buschiazzo, None; G. Citera, None.

To cite this abstract in AMA style:

Gallino Yanzi J, Schneeberger E, Cerda OL, Zaffarana C, Landi M, Rosemffet MG, Zamora N, Cazenave T, Dal Pra F, Kohan P, Buschiazzo E, Citera G. Construct Validity of Disease Activity for Psoriatic Arthritis Composite Index and Tentative Cut-Off Values in a Cohort of Patients with Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/construct-validity-of-disease-activity-for-psoriatic-arthritis-composite-index-and-tentative-cut-off-values-in-a-cohort-of-patients-with-psoriatic-arthritis/. Accessed December 10, 2019.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/construct-validity-of-disease-activity-for-psoriatic-arthritis-composite-index-and-tentative-cut-off-values-in-a-cohort-of-patients-with-psoriatic-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

Annual Meeting in Atlanta, Georgia

© COPYRIGHT 2019 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.