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Abstract Number: 568

Complement Consumption As a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational Study

Alisson Pugliesi1, RACHEL ZERBINI MARIANO2, Raquel Baldini Campos3, Simone Appenzeller4, Manoel Bertolo5 and ZORAIDA SACHETTO1, 1INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 2Radiology and Diagnostic Imaging, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 3Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 4Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, 5INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: Lung Disease, Sjogren's syndrome and complement

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Session Information

Date: Sunday, November 5, 2017

Session Title: Sjögren's Syndrome Poster I: Translational Research

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Complement Consumption as a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational Study

Background/Purpose: Primary Sjögren’s syndrome (pSS) may present with respiratory manifestations ranging from proximal and distal airways impairment to various forms of interstitial lung disease (pSS-ILD), which can affect up to 16% of patients1. Studies on factors associated with pulmonary manifestations of pSS are few and of heterogeneous results2,3,4. Our main objective was to identify clinical and laboratory elements related to pSS that may be predictors of lung disease.

Methods: Retrospective study of pSS patients in follow-up at a university hospital. Patients older than 18 years who met pSS classificatory criteria according to the American-European Consensus of 2002 were included. Patients with other CTD were excluded. Epidemiological, clinical, and laboratory data were extracted from medical records. Chest CT scans were reviewed by a radiologist without knowledge of the patients’ clinical data. Data from patients with pSS with and without pulmonary manifestations were compared and Fischer’s test was applied for statistical evaluation.

Results: Seventy patients with pSS were selected (68% female and mean age 45.8 ± 9.5). Fifteen (21.4%) had some form of pulmonary manifestation, 14 (20%) of ILD and 1 of bronchiolitis (1.4%). Among the analyzed variables, a statistically significant association was found between complement consumption (C3 or C4) and presence of pulmonary manifestation (38.4% versus 10.2%; p: 0.02). No association was found between autoantibodies such as ANA, RF, Ro/SSA and La/SSB or other forms of extraglandular manifestation (Table 1). No variables were correlated with the presence of pulmonary cysts or pSS-ILD. The radiological findings of patients with pulmonary manifestations are summarized in Table 2.

Conclusion: In our series of patients with pSS, we found a high frequency of individuals with pSS and pulmonary impairment. Complement consumption was a predictor of this form of manifestation, an association never seen before.

 


Disclosure: A. Pugliesi, None; R. Z. MARIANO, None; R. Baldini Campos, None; S. Appenzeller, None; M. Bertolo, None; Z. SACHETTO, None.

To cite this abstract in AMA style:

Pugliesi A, MARIANO RZ, Baldini Campos R, Appenzeller S, Bertolo M, SACHETTO Z. Complement Consumption As a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational Study [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/complement-consumption-as-a-predictor-of-pulmonary-manifestation-in-patients-with-primary-sjogrens-syndrome-results-from-a-unicentric-observational-study/. Accessed January 18, 2021.
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