ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2590

Comparison of Radiographic Damage Score in Ankylosing Spondylitis According to Tumor Necrosis Factor Inhibitor: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) Data

Tae-Jong Kim1, JI Hui SHIN2, Il-Hoon Sung3, Seunghun Lee4, Kyung-Bin Joo5 and Tae-Hwan Kim6, 1Chonnam Nat`l University Medical School&Hospital, Gwangju, South Korea, 2Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Orthopaedic surgery, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 4Department of Radiology, Department of Radiology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 5Department of Radiology, Department of Radiology, Hanynag University Hospital for Rheumatic Diseases, Seoul, South Korea, 6Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment III

Session Type: Abstract Submissions (ACR)

Background/Purpose

To evaluate the influence of tumor necrosis factor (TNF) blocker on the radiographic damage in ankylosing spondylitis (AS).

 Methods .

A total of 610 AS patients from the Observation Study of Korean spondyloArthropathy Registry (OSKAR) data were recruited for this study. The subjects were stratified in relation to the using state of TNF blocker. We evaluated collected clinical and radiographic parameters at two different time points. Then we compared radiographic progression between groups. To use the mSASSS, cervical and lumbar spinal radiographs were examined. Univariable and multivariable regression analyses were done after adjusting for potential confounding factors, such as age, gender, disease duration, history of eye involvement, history of peripheral arthritis, juvenile onset AS, baseline CRP level, baseline mSASSS, and NSAID intakes.

 Results .

The mean age (SD) of the AS patients was 37.9(18.3) years, and the mean disease duration (SD) was 17.3 (18.3) years at baseline. In this data, 88.7% of the patients were male, and 96.9% were HLA–B27 positive. 40.7% of the patients had history of peripheral arthritis. Of these patients, 44.1% (269 patients) had received TNF blockers. The mean mSASSS unit (SEM) at baseline was significantly different between groups (TNF blocker naïve 17.6±0.9 vs TNF blocker user 21.0±1.2, P = 0.02). Radiographic follow-up duration from the first mSASSS assessment were comparable (4.9±0.1 vs 5.1±0.1, P = 0.28). However, Patients treated with TNF blockers had a higher CRP level (2.5±0.2 vs 1.6±0.1, p <0.01) at baseline. On simple analysis, the TNF blocker naïve patients had comparable radiographic progression to those with TNF blocker (3.7±0.5 vs 3.7±0.8, p = 0.99). After adjustment for multiple comparisons by the Bonferroni correction, gender, history of peripheral arthritis, disease duration, baseline mSASSS, and NSAID intake had statistically significance in our registry. However, the radiographic progression between groups was no significant difference (OR 0.60, [95% CI 0.22-4.72], P = 0.44).

 Conclusion .

Treatment with TNF inhibitors has no influence on radiographic progression in AS.

Disclosure:

T. J. Kim,
None;

J. H. SHIN,
None;

I. H. Sung,
None;

S. Lee,
None;

K. B. Joo,
None;

T. H. Kim,
None.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/comparison-of-radiographic-damage-score-in-ankylosing-spondylitis-according-to-tumor-necrosis-factor-inhibitor-observation-study-of-korean-spondyloarthropathy-registry-oskar-data/