ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2464

Comparison of Disease Activity Score (DAS) 28-CRP to DAS28-ESR in Patients with Active Rheumatoid Arthritis

In Ah Choi, Division of Rheumatology, Department of Internal Medicine, Division of Rheumatology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, The Republic of

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Disease Activity and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, November 15, 2016

Session Title: Rheumatoid Arthritis – Clinical Aspects - Poster III: Treatment – Monitoring, Outcomes, Adverse Events

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Assessment of disease activity is a key part of clinical decision in rheumatology care. High disease activity presented by disease activity score 28 ((DAS28) > 5.1 is used as a cutoff for biologic use in many countries include Korea. This study is to find confounding factors affecting erythrocyte sedimentation ratio (ESR) and C-reactive protein (CRP) to patients with rheumatoid arthritis to find the best tool to access rheumatoid arthritis (RA) disease activity, and to compare DAS28-ESR and DAS28-CRP to see whether we can use these indices interchangeably.

Methods:  A cross-sectional study was conducted in 1117 patients with RA, using initial registration data from Korean Biologics Registry (KOBIO).

Results: ESR levels were increased with age (r = 0.120, p < 0.001) and serum rheumatoid factor (r = 0.111, p = 0.001) but did not correlate with BMI, disease duration, and anti-CCP antibody titer. There were no differences in ESR levels according to the gender, smoking status, presence of diabetes mellitus, obesity (BMI ≥ 30) or low body weight (BMI < 20). CRP levels did not correlate with age, BMI, disease duration, RF and anti-CCP antibody. They were higher in female compared to male (p < 0.001) and higher in never-smoker compared to ever-smoker (p = 0.003). However, those differences of CRP levels were not significant when stratified by smoking status and gender, respectively. There were no differences in CRP levels according to the presence of diabetes mellitus, obesity (BMI ≥ 30) or low body weight (BMI < 18.5). In comparison of composite indices, DAS28CRP showed excellent correlation with DAS28ESR (r = 0.943, p < 0.001). However, in defining high disease activity, DAS28CRP showed only a fair agreement with DAS28ESR (kappa 0.381). To make best agreement with DAS28ESR in defining high disease activity, DAS28CRP need to be lowered to 4.5 (kappa 0.679, sensitivity 85.8%, specificity 88.0%, AUC 0.936).

Conclusion: DAS28CRP is a useful marker for inter-patient-comparison of RA disease activity when comparing patients with different age or rheumatoid factor status. DAS28CRP correlates well with DAS28ESR but the cutoff for high disease activity needs to be lowered to 4.5 to be used interchangeably with DAS28ESR in defining high disease activity.


Disclosure: I. A. Choi, None;

To cite this abstract in AMA style:

Choi IA. Comparison of Disease Activity Score (DAS) 28-CRP to DAS28-ESR in Patients with Active Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/comparison-of-disease-activity-score-das-28-crp-to-das28-esr-in-patients-with-active-rheumatoid-arthritis/. Accessed January 25, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/comparison-of-disease-activity-score-das-28-crp-to-das28-esr-in-patients-with-active-rheumatoid-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.