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Abstract Number: 1109

Comparison of Diagnostic Criteria in Behçet’s Disease and Sensitivity in Diagnosing Severe Manifestations

Carmen Álvarez-Reguera1, Alba Herrero-Morant1, Lara Sánchez-Bilbao1, David Martinez-Lopez1, José Luis Martin-Varillas2, Guillermo Suárez-Amorin1, Maria Cristina Mata-Arnaiz3, Miguel Ángel gonzalez-Gay4 and Ricardo Blanco5, 1Hospital Universitario Marqués de Valdecilla, Santander, Spain, 2Hospital Sierrallana, Torrelavega, Spain, 3Hospital de Laredo, Spain, Spain, 4Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, Division of Rheumatology, Hospital Universitario Marqués de Valdecilla; School of Medicine, Universidad de Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa, 5Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain

Meeting: ACR Convergence 2021

Keywords: Behçet's Syndrome, Diagnostic criteria, SEVERE

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Session Information

Date: Monday, November 8, 2021

Session Title: Miscellaneous Rheumatic & Inflammatory Diseases Poster II: Clinical Features & Diagnostics (1083–1117)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: Behçet disease (BD) is characterized by painful recurrent oral aphthosis genital ulcers and skin lesions. Nevertheless, the major causes of morbidity result from ocular, vascular and neurological involvement. Diagnosis of BD is usually performed according to the International Study Group (ISG) (Lancet 1990; 335:1078-80). Recently, criteria proposed by the International Team for the Revision of the International Criteria for BD (ITR-ICBD) have demonstrated a higher sensitivity (J Eur Acad Dermatology Venereol 2014;28:338-47).

The aim of the present study was to assess a) the concordance and differences between ISG and ICDB criteria b) sensitivity in diagnosing severe manifestations (ocular, vascular and neurological).

Methods: The study included 120 patients diagnosed with definitive or possible BD by expert rheumatologists. They were diagnosed at a well-defined population in Northern Spain between January 1980 and December 2019. The ISG and ICBD diagnostic criteria for BD were applied to all patients and compared among them.

Results: 120 patients (62 men/ 58 women) were studied. Mean age at diagnosis was 37.6±13.8 years. 59 (49.2%) patients fulfilled ISG criteria and 96 (80%) ICBD criteria. Concordance between both criteria was moderate (Kappa 0.41). ICBD criteria diagnosed more patients with neurological (χ²=49.1, p< 0.01), vascular (χ²= 56.7, p< 0.01) and ocular manifestations (χ²=84.4 p< 0.01) (Figure).

Conclusion: ICBD criteria are more likely to diagnose BD and classify more patients with severe manifestations of the disease.


Disclosures: C. Álvarez-Reguera, None; A. Herrero-Morant, None; L. Sánchez-Bilbao, None; D. Martinez-Lopez, None; J. Martin-Varillas, None; G. Suárez-Amorin, None; M. Mata-Arnaiz, None; M. gonzalez-Gay, None; R. Blanco, Brystol Myers Squibb, 6.

To cite this abstract in AMA style:

Álvarez-Reguera C, Herrero-Morant A, Sánchez-Bilbao L, Martinez-Lopez D, Martin-Varillas J, Suárez-Amorin G, Mata-Arnaiz M, gonzalez-Gay M, Blanco R. Comparison of Diagnostic Criteria in Behçet’s Disease and Sensitivity in Diagnosing Severe Manifestations [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/comparison-of-diagnostic-criteria-in-behcets-disease-and-sensitivity-in-diagnosing-severe-manifestations/. Accessed January 30, 2023.
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