ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1289

Comparison of Clinical Parameters and PET/MRI in Juvenile Idiopathic Arthritis

Kathleen Jo Corbin1, Emily von Scheven1, Youngho Seo2, Spencer Behr2 and John MacKenzie3, 1Division of Rheumatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, 2Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, 3Section of Pediatric Radiology, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Imaging, juvenile idiopathic arthritis (JIA), magnetic resonance imaging (MRI) and positron emission tomography (PET)

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, November 14, 2016

Title: Imaging of Rheumatic Diseases - Poster II: XR/CT/PET/MRI

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Positron emission tomography (PET) can be used to identify inflammation using 18F-fluorodeoxyglucose (18F-FDG).  18F-FDG uptake correlates with clinical and laboratory markers of disease activity in adults with rheumatoid arthritis and in one previous study of juvenile idiopathic arthritis (JIA).  The purpose of this study was to test the feasibility of combining the metabolic data from 18F-FDG PET with structural and functional data from MRI to assess disease activity in JIA.

Methods: Seven patients with polyarticular JIA according to ILAR criteria (6 RF-positive, 1 RF-negative) underwent 18F-FDG PET/MRI of the whole body and a dedicated scan of 1 joint/region.  Each patient had a complete joint exam on the day of the scan.  Patients were scanned using a weight-based, low-dose (0.5 megabecquerel/kg) 18F-FDG protocol to minimize radiation exposure, resulting in maximum effective dose less than 0.7 millisievert for patients weighing 55 kg or greater.  Images were evaluated qualitatively, and joints were considered positive on PET if 18F-FDG localization was increased above background. 

Results: Mean age was 15.1±2.9 yrs and median disease duration was 7.5±2.4 yrs.  For 4 out of 7 patients, PET showed more positive joints than physical exam (see table).  For 1 patient, physical exam showed 2 positive joints but PET was negative.  Joints that showed disagreement between physical exam and PET included hand/wrist, ankle/foot, knee, elbow, and shoulder (see Figure 1).  Disagreement between physical exam and PET did not correlate with any clinical characteristics including ESR, BMI, or Juvenile Arthritis Disease Activity Score (JADAS).  MRI allowed localization of PET signal, for example allowing diagnosis of tenosynovitis in one patient (see Figure 2).

Conclusion: We found disagreement between physical exam and PET in 5 out of 7 JIA patients.  PET detected more joints with inflammation than physical exam, and notably this disagreement often occurred in joints that are easily accessible on physical exam.


Disclosure: K. J. Corbin, None; E. von Scheven, None; Y. Seo, None; S. Behr, None; J. MacKenzie, None.

To cite this abstract in AMA style:

Corbin KJ, von Scheven E, Seo Y, Behr S, MacKenzie J. Comparison of Clinical Parameters and PET/MRI in Juvenile Idiopathic Arthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/comparison-of-clinical-parameters-and-petmri-in-juvenile-idiopathic-arthritis/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/comparison-of-clinical-parameters-and-petmri-in-juvenile-idiopathic-arthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology