Session Information
Date: Monday, October 22, 2018
Title: Vasculitis Poster II: Behҫet’s Disease and IgG4-Related Disease
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Systemic vasculitis is one of the major manifestations of Behcet’s disease (BD). Takayasu’s arteritis (TA) is a chronic vasculitis that primarily affects the aorta and its branch. While BD and TA differ in their clinical characteristics, it is difficult to differentiate them in particular when BD presented with major arterial involvement. Our study was to compare clinical characteristics and angiographic findings between TA and BD patients with arterial involvement.
Methods: We retrospectively reviewed medical records of 206 TA patients and 50 BD patients between 1995 and 2015. Angiographic lesions were evaluated based on CT, MRI and/or angiography findings. The diagnosis was confirmed according to the American College of Rheumatology 1990 criteria for TA and the International Criteria for BD.
Results: Patients with TA were more likely female than those with BD (83.5% vs 40.0%, p = 0.000). In clinical manifestation, fever (9.2% vs 30.0%, p = 0.000) and arthralgia (7.3% vs 36.0%, p = 0.000) were more frequently seen in patients with BD. Serum levels of C-reactive protein was significantly higher (2.08mg/dL vs 5.84mg/dL, p=0.000) in BD than in TA. Stenosis (89.8% vs 60%, P=0.000) and occlusion (65.5% vs 32%, P=0.000) were more frequently observed in patients with TA than in those with BD. In contrast, BD patients were more likely to have aneurysmal lesions (62% vs 20.9%, P=0.000). In terms of the site of vascular lesions, subclavian artery (71.4% vs 16%, p=0.000), carotid artery (73.3% vs 30%, p=0.000), descending aorta (35% vs 12%, p=0.002), brachiocephalic trunk (13.6% vs 2%, p=0.020), superior mesenteric artery (18.4% vs 4%, p=0.012) and renal artery (23.8% vs 10%, p=0.032) were more commonly involved in TA, whereas femoral artery (10% vs 2.4%, p=0.027) was more frequently involved in patients with BD.
Conclusion: TA patients differ from BD patients with arterial involvement in terms of clinical features and vascular involvement pattern.
Table 1. Angiographic findings in TA and BD with arterial involvement.
|
Stenosis |
Occlusion |
Dilatation |
Aneurysm |
|||||
|
TA (n=206) |
BD (n=50) |
TA (n=206) |
BD (n=50) |
TA (n=206) |
BD (n=50) |
TA (n=206) |
BD (n=50) |
|
|
All |
89.8% |
60%*** |
65.5% |
32%*** |
26.7% |
30%NS |
20.9% |
62%*** |
|
Aorta |
41.7% |
6%*** |
3.9% |
0%NS |
11.7% |
20%NS |
11.7% |
46%*** |
|
Arteries of head and neck |
69.4% |
30%*** |
34.5% |
8%*** |
10.2% |
12%NS |
8.7% |
8%NS |
|
Arteries of upper extremity |
42.2% |
8%*** |
38.3% |
2%*** |
2.9% |
2%NS |
5.3% |
6%NS |
|
Arteries of abdomen |
31.6% |
14%* |
11.2% |
6%NS |
3.9% |
2%NS |
2.4% |
6%NS |
|
Arteries of pelvis and lower extremity |
6.3% |
6%NS |
3.9% |
10%NS |
1% |
0% |
1% |
12%** |
NS, P≥0.05; *, P<0.05 ; **, P<0.01; and ***, P<0.001
To cite this abstract in AMA style:
Choi SJ, Lim DH, Oh JS, Hong S, Kim YG, Lee CK, Yoo B. Comparison of Clinical and Angiographic Features of Arterial Involvement in Takayasu’s Arteritis and Behcet’s Disease [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/comparison-of-clinical-and-angiographic-features-of-arterial-involvement-in-takayasus-arteritis-and-behcets-disease/. Accessed .« Back to 2018 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/comparison-of-clinical-and-angiographic-features-of-arterial-involvement-in-takayasus-arteritis-and-behcets-disease/