Session Type: Abstract Submissions (ACR)
Clinical Predictors for subcutaneous Power Doppler signals detected by ultrasound in scleroderma patients
Skin thickening in scleroderma was demonstrated previously in US studies, although subcutaneous tissue was not yet evaluated. We evaluated scleroderma patients for subcutaneous Power Doppler signal (SCPD) on the dorsal aspect of the MCPs of the dominant hand. Out of 74 patients, 17 (22.9%) had a positive signal. Our aim was to compare SCPD positive (N= 17, 22.9%) versus SCPD negative (N=57, 77.1%) patients and to look for clinical and laboratory predictors for SCPD.
Seventeen SCPD positive patients were compared with 57 SCPD negative patients. US exam was performed using GE logic E9 scanner with a linear array (5-16 MHz) for PD in subcutaneous tissue. SCPD was defined as a positive PD signal in the subcutaneous tissue on the dorsal aspect of either MCPs 2-5 in both longitudinal and short views that was not involving the tendon. At least one MCP had to be involved. A binary grading was used to score SCPD (0-1). Patients were divided into 2 groups, with or without SCPD. GS and PD examinations of 13 joints (wrist, MCP 2-5, PIPs 2-5) and tendons were done. A step wise linear regression model was used to identify predictors for SCPD. The following parameters were included: age, gender, disease duration, disease type (limited or diffuse), modified Rodnan skin score (MRSS), lung involvement (symptoms, pulmonary function test and high resolution CT) , pulmonary hypertension (echo), ESR, CRP, ulcers, calcinosis, sclerodactaly and contractures.
After univariate analysis with P<0.2 cut-off, MRSS, disease duration and lung involvement were included. MRSS (OR=0.93, p=0.14) and lung disease(OR=0.28, p=0.047) decreased the likelihood for SCPD while longer disease duration increased its likelihood (OR=1.117, p=0.036). The final model included only lung and disease duration with a ROC curve, AUC of 0.77 (figure 1). There was no statistical difference in mean joint GS and PD between both groups (mean joint GS 0.34 and 0.31 in the negative and positive SCPD patients respectively, mean joint PD 0.08 and 0.04 in the negative and positive SCPD patients respectively). Mean ESR was 21 and 18 mm/h in the positive and negative SCPD patients respectively (P value 0.94).
Twenty two percent of patients with scleroderma had positive subcutaneous power doppler signal above the dorsal aspect of the MCPs. Patients with this phenomenon had longer disease duration and less lung involvement with moderately good predictive value ( ROC AUC- 77). There was not increased synovitis or elevated ESR in this group. We therefore assume that this is not an inflammatory phenomenon. We speculate that SCPD may be related to increased blood flow to the skin during the resolution phase of the skin. Further studies are needed to understand the underling mechanism.
V. K. Ranganath,
P. J. Clements,
Actelion Pharmaceuticals US,
Novartis Pharmaceutical Corporation,
Janssen Pharmaceutica Product, L.P.,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/clinical-predictors-for-subcutaneous-power-doppler-signals-detected-by-ultrasound-in-hands-of-scleroderma-patients/