Clinical Characteristics of Inflammatory Myopathies Associated with Cancer: A Report from the Remicam Registry

Isabel de la Cámara Fernández¹, Patricia Carreira², Beatriz E. Joven³, Francisco Javier López Longo⁴, Tatiana Cobo-Ibáñez⁵, Leticia Lojo⁶, Carmen Larena⁷, Carmen Barbadillo⁸, Julia Martínez-Barrio⁹, Juan Carlos Lopez-Robledillo¹⁰, Paloma Garcia De La Peña¹¹, Eva Tomero¹², Irene Llorente¹³, Henry Moruno Cruz¹⁴, Ana Pérez Gómez¹⁴, Laura Nuño¹⁵, Raquel Almodóvar González¹⁶, VALENTINA MALDONADO¹⁷, Lucía Ruiz Gutiérrez¹⁴ and MARIA JESUS GARCIA DE YEBENES Y PROUS¹⁸, ¹RHEUMATOLOGY, RHEUMATOLOGY DEPARTMENT. HOSPITAL 12 DE OCTUBRE, MADRID, Spain, ²Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ³Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁴Rheumatology, Hospital Gregorio Marañón, Madrid, Spain, ⁵Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, ⁶Rheumatology, Hospital Universitario La Paz, Spain, Spain, ⁷Hospital Gregorio Marañón, Madrid, Spain, ⁸Hospital Universitario Puerta de Hierro, Madrid, Spain, ⁹Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹⁰Hospital Niño Jesus, Madrid, Spain, ¹¹Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ¹²Hospital La Princesa. Madrid., Madrid, Spain, ¹³Rheumatology, H.U. La Princesa, Madrid, Spain, ¹⁴University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, ¹⁵Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Spain, ¹⁶Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain, ¹⁷RHEUMATOLOGY, RHEUMATOLOGY DEPARTMENT. HOSPITAL RAMON Y CAJAL, MADRID, Spain, ¹⁸INSTITUTO DE SALUD MUSCULOESQUELÉTICA, MADRID, Spain

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Cancer and myositis

Session Information

Date: Sunday, November 13, 2016

Title: ARHP I: Exemplary Abstracts

Session Type: ARHP Concurrent Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: To describe the clinical presentation and associations of patients with IM associated with cancer in a large group of inflamatory myopathy (IM) from the multicentric REMICAM registry

Methods: A multicenter retrospective study from the REMICAM registry was performed. Patients older than 40 years at diagnosis were selected. All patients were diagnosed with IM according to Bohan and Peter criteria, followed between Jan 1980 and Dec 2014 and classified into 7 different clinical subgroups: primary dermatomyositis (DM), primary polymyositis (PM), cancer associated myositis (CAM), overlap myositis (OM), inclusion body myositis (IBM) and necrotizing myositis (NM). Only cancers diagnosed within 3 years of IM diagnosis were considered as CAM. Descriptive statistics, univariate and multivariate analysis were performed. Kaplan Meyer curves with long-rank analysis were used for survival.

Results: From 283 patients (72% w, 60±11 y at diagnosis, 9±7 y of follow-up, 39% DM, 61% PM), 64 (23%) presented any type of cancer: 11 lung, 8 hematological, 8 skin, 7 breast, 4 colon, 4 stomach, 4 ovary, 4 bladder, 3 endometrium, 3 prostate and 8 others. Median time between IM and cancer was 5 months. In multivariate analysis, patients with cancer were more frequently men (p<.0001), with DM (p=.005) and presented more ischemic lesions (p<.0001). No other clinical findings were different between patients with or without cancer. Mortality was higher in patients with cancer, with a median survival of 10±3 years, compared to 22±3 years for patients without cancer (p<.0001). From the CAM group, 41 (64%) patients died, mainly as a consequence of cancer.

Conclusion: In our registry, over 20% of patients older than 40 years presented IM associated with cancer. This type of IM is more common in men and present as dermatomyositis with ischemic lesions. As expected, mortality is highly increased in IM patients with cancer.

Disclosure: I. de la Cámara Fernández, None; P. Carreira, None; B. E. Joven, None; F. J. López Longo, None; T. Cobo-Ibáñez, None; L. Lojo, None; C. Larena, None; C. Barbadillo, None; J. Martínez-Barrio, None; J. C. Lopez-Robledillo, None; P. Garcia De La Peña, FUNDACION ESPAÑOLA DE REUMATOLOGIA, 2; E. Tomero, None; I. Llorente, None; H. Moruno Cruz, None; A. Pérez Gómez, None; L. Nuño, None; R. Almodóvar González, None; V. MALDONADO, None; L. Ruiz Gutiérrez, None; M. J. GARCIA DE YEBENES Y PROUS, None.

To cite this abstract in AMA style:

de la Cámara Fernández I, Carreira P, Joven BE, López Longo FJ, Cobo-Ibáñez T, Lojo L, Larena C, Barbadillo C, Martínez-Barrio J, Lopez-Robledillo JC, Garcia De La Peña P, Tomero E, Llorente I, Moruno Cruz H, Pérez Gómez A, Nuño L, Almodóvar González R, MALDONADO V, Ruiz Gutiérrez L, GARCIA DE YEBENES Y PROUS MJ. Clinical Characteristics of Inflammatory Myopathies Associated with Cancer: A Report from the Remicam Registry [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/clinical-characteristics-of-inflammatory-myopathies-associated-with-cancer-a-report-from-the-remicam-registry/. Accessed .

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