ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 946

Clinical and Serological Features of Systemic Sclerosis in a Multicenter African American Cohort: Analysis of the Genome Research in African American Scleroderma Patients Clinical Database

Nadia D. Morgan1, Ami A. Shah1, Maureen D. Mayes2, Robyn T. Domsic3, Thomas A. Medsger Jr.4, Virginia D. Steen5, John Varga6, Mary A. Carns7, Paula S. Ramos8, Richard M. Silver9, Elena Schiopu10, Dinesh Khanna10, Vivien Hsu11, Jessica K. Gordon12, Heather Gladue13, Lesley A. Saketkoo14, Lindsey A. Criswell15, Chris T. Derk16, Marcin A. Trojanowski17, Victoria K. Shanmugam18, Lorinda Chung19, Antonia Valenzuela20, Reem Jan21, Avram Goldberg22, Elaine F. Remmers23, Daniel L. Kastner23, Fredrick M. Wigley24, Pravitt Gourh25 and Francesco Boin26, 1Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 3Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, 5Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 6Rheumatology and Dermatology, Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 7Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 8Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 9Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 10University of Michigan, Ann Arbor, MI, 11Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, 12Rheumatology, Hospital for Special Surgery, New York, NY, 13Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, 14Rheumatology, Tulane University School of Medicine, New Orleans, LA, 15Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 16Rheumatology, University of Pennsylvania, Philadelphia, PA, 17Boston University School of Medicine, Boston, MA, 18Rheumatology, The George Washington University, Washington, DC, 19Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 20Stanford University School of Medicine, Stanford, CA, 21Medicine, Rheumatology, University of Chicago, Chicago, IL, 22NYU Langone Medical Center, New York, NY, 23National Institutes of Health (NIH), National Human Genome Research Institute, Bethesda, MD, 24Rheum Div/Mason F Lord, Johns Hopkins University, Baltimore, MD, 25NIAMS-Rheumatology, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, 26Rheumatology, University of California, San Francisco, San Francisco, CA

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: African-Americans and systemic sclerosis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Sunday, November 5, 2017

Session Title: Systemic Sclerosis, Fibrosing Syndromes and Raynaud's – Clinical Aspects and Therapeutics I

Session Type: ACR Concurrent Abstract Session

Session Time: 4:30PM-6:00PM

Background/Purpose:

Racial differences exist in the severity of systemic sclerosis (SSc). To enhance our knowledge about SSc in African Americans, we established a comprehensive clinical database from the largest multicenter cohort of African American SSc patients assembled to date (the Genome Research in African American Scleroderma Patients (GRASP) cohort). We compared the phenotypic manifestations of SSc in the GRASP cohort to that reported in the European League Against Rheumatism Scleroderma Trials and Research (EUSTAR) cohort1.

Methods:

African American SSc patients were enrolled retrospectively and prospectively over a 30-year period (1987 to 2016), from 18 academic centers throughout the United States. 945 (94%) patients met the 2013 ACR/EULAR classification criteria for SSc, with the remaining 64 (6%) meeting the 1980 ACR or CREST criteria. The cross-sectional prevalence of sociodemographic, clinical and serological features was evaluated using data obtained at the time of study enrollment. Factors associated with clinically significant manifestations of SSc were assessed using multivariate logistic regression analyses.

Results:

The study population included a total of 1009 African American SSc patients comprised of 84% women. While 43% were actively employed, 33% required disability support. The majority (57%) had the more severe diffuse subtype and a young age at symptom onset (39.1±13.7 years), in marked contrast to that reported in the EUSTAR cohort.  11% of patients had a severe Medsger cardiac score2 of 4 (Figure 1). Pulmonary fibrosis evident on computed tomography (CT) chest was present in 43% of patients, and was significantly associated with anti-topoisomerase I positivity (Table 1). 38% of patients with CT evidence of pulmonary fibrosis had a severe restrictive ventilator defect with forced vital capacity (FVC) £50% predicted. 16% of patients in the GRASP cohort required oxygen therapy compared to 3% in the EUSTAR cohort. A significant association was noted between longer disease duration and higher odds of pulmonary hypertension (Table 1). The prevalence of potentially fatal scleroderma renal crisis was 7%, 3.5 times higher than that reported in the EUSTAR cohort.

Conclusion:

Our study emphasizes the unique and severe disease burden of SSc in African Americans compared to those of European ancestry.

1.         Meier FM, et al. Update on the profile of the EUSTAR cohort: an analysis of the EULAR Scleroderma Trials and Research group database. Ann Rheum Dis. 2012;71:1355-60.

2.         Medsger TA, Jr., et al. Assessment of disease severity and prognosis. Clin Exp Rheumatol. 2003;21:S42-6.




Disclosure: N. D. Morgan, None; A. A. Shah, None; M. D. Mayes, None; R. T. Domsic, None; T. A. Medsger Jr., None; V. D. Steen, None; J. Varga, BMS, 2,Pfizer Inc, 2; M. A. Carns, None; P. S. Ramos, None; R. M. Silver, None; E. Schiopu, None; D. Khanna, Actelion, Bayer, BoehringerIngelheim, Chemomab, Corbus, Covis, Cytori,Eicos, EMD Serono, Genentech/Roche, Gilead, GSK, Sanofi-Aventis,UCB Pharma, 5,NIH/NIAMS, NIH/NIAID,Bayer, BMS, Genentech/Roche, Pfizer, 2,Eicos, 4; V. Hsu, None; J. K. Gordon, None; H. Gladue, None; L. A. Saketkoo, None; L. A. Criswell, None; C. T. Derk, None; M. A. Trojanowski, None; V. K. Shanmugam, Multiple, 9; L. Chung, Cytori, Actelion, Reata, 5; A. Valenzuela, None; R. Jan, None; A. Goldberg, None; E. F. Remmers, None; D. L. Kastner, None; F. M. Wigley, None; P. Gourh, None; F. Boin, None.

To cite this abstract in AMA style:

Morgan ND, Shah AA, Mayes MD, Domsic RT, Medsger TA Jr., Steen VD, Varga J, Carns MA, Ramos PS, Silver RM, Schiopu E, Khanna D, Hsu V, Gordon JK, Gladue H, Saketkoo LA, Criswell LA, Derk CT, Trojanowski MA, Shanmugam VK, Chung L, Valenzuela A, Jan R, Goldberg A, Remmers EF, Kastner DL, Wigley FM, Gourh P, Boin F. Clinical and Serological Features of Systemic Sclerosis in a Multicenter African American Cohort: Analysis of the Genome Research in African American Scleroderma Patients Clinical Database [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/clinical-and-serological-features-of-systemic-sclerosis-in-a-multicenter-african-american-cohort-analysis-of-the-genome-research-in-african-american-scleroderma-patients-clinical-database/. Accessed January 18, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/clinical-and-serological-features-of-systemic-sclerosis-in-a-multicenter-african-american-cohort-analysis-of-the-genome-research-in-african-american-scleroderma-patients-clinical-database/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.