Background/Purpose: To assess clinical and serological differences between patients with juvenile-onset systemic lupus erythematosus (jSLE) and adult-onset (aSLE) from a National database.Methods: Data included in the transverse phase of the National Register of lupus of the Spanish Society of Rheumatology (RELESSER –T) were analysed, which includes retrospective data from SLE patients. Inclusion criteria: patients with SLE with > or = 4 ACR criteria for SLE who were divided into 2 groups: disease date onset < 18 years and > 18. Sociodemographic, clinical, serological, activity, treatment and cumulative damage and chronicity data were collected. Associative descriptive statistical analysis was performed.Results: we reviewed 3.428 aSLE (89.6 % women) and 484 jSLE (89.8 % girls), 93.1 % Caucasian in both groups; age at diagnosis: 38.1±14 and 16.6 ± 6.3 years, respectively; average delay in diagnosis 24.7±47.4 and 39.9±5 months, respectively; mean age at followup: 48.8 ± 14.3, 31.5 ± 30 years, respectively. Table 1 shows all significant differences (p <0.05). In aSLE 68.7 % had positive anti-DNA Ab vs. 82.9 % of jSLE (p < 0.001). Table 1

Conclusion: jSLE have higher percentage of nephritis, hypertension (associated with nephritis), anti-DNA, Creat clearance < 5, proteinuria > 3.5, recurrent nephritis, chronic renal failure, organic brain syndrome and thrombotic thrombocytopenic purpura and more SLE family background. jSLE also have higher SLEDAI, Katz, but lower Charlson scores. Secondary Sjögren (anti-RO), fibromyalgia and osteoporosis are more common in aSLE. jSLE receive more steroid treatment, synthetic immunosuppressants, IV immunoglobuline, rituximab, splenectomy, dialysis and kidney transplantation.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/clinical-and-serological-differences-between-juvenile-onset-and-adult-onset-systemic-lupus-erythematosus-patients-from-a-national-registry-of-patients/