Date: Monday, November 6, 2017
Session Title: Patient Outcomes, Preferences, and Attitudes Poster II
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: The use of patient reported outcomes(PROs) has become increasingly popular in the chronic disease management, disease monitoring and the assessment of drug efficacy. However, very few studies on rheumatoid arthritis (RA) have come down to PROS in China. We initiated CPRI-RA based on Chinese RA population, which include not only arthritis symptoms, physical function but also fatigue, appetite, emotional wellness and self-efficacy. We aimed to measure the reliability and the validity of CPRI-RA and evaluate the correlation and agreement with DAS28 and HAQ.
Methods: Nationwide multicenter cross-sectional and longitudinal studies were designed to recruit RA patients who fulfilled 1987 ACR classification criteria. Demographics, clinical and laboratory data were collected and CPRI-RA, DAS-28 and HAQ were recorded. Intensive treated patients with moderately to severely active RA were followed up regularly for 12-week and 24-week periods to track the changes of CPRI-RA, DAS-28 and HAQ scores. The reliability was measured using the Cronbach α coefficient and the validity was analyzed by the construct validity using factor analysis method. Agreement between CPRI-RA and DAS28 was analyzed by the weighted kappa value. The correlation between CPRI-RA and DAS28, HAQ was analyzed by Pearson correlations. The linear mixed-effects model was adopted to analyze the dynamic correlation and consistency between the indices.
Results: A total of 1868 RA patients (83.08% women, mean±SD age 54.79±12.62 years, disease duration 6.18±7.68 years, DAS28 5.56±1.36) from 19 provinces and 23 hospitals completed the cross-sectional survey and 186 active RA patients(85.48% women, mean±SD age 48.18±10.61 years, disease duration 1.77±1.52 years, DAS28 5.71±1.06) participated in the longitudinal study. The overall Cronbach α value was 0.756 and the Guttman spit-half coefficient was 0.733, indicating CPRI-RA had good internal consistency and stability. Three factors extracted by factor analysis (cumulative 53.199%) reflected the physical status, social and psychological properties of RA patients, which provided evidence for good construct validity. HAQ versus CPRI-RA scores were significantly correlated (r=0.581, P<0.0001), and DAS28 versus CPRI-RA scores were significantly correlated at higher levels (r=0.640, P<0.0001). The weighted kappa value was 0.4215 (P <0.0001) for DAS28 versus CPRI-RA, indicating fair agreement of the indices. Dynamically, HAQ versus CPRI-RA scores and DAS28 versus CPRI-RA scores were both significantly correlated (r=0.4464, r=0.4622, P<0.0001). The dynamic trends of the three indices were highly consistent.
Conclusion: CPRI-RA, a reliable, feasible and valid PRO scale, can provide similar quantitative information to DAS28 and HAQ. The results support the incorporating of CPRI-RA into the routine assessment and dynamic monitoring of RA.
To cite this abstract in AMA style:Han M, Gong X, Tang XP, Liu HX, Liu J, Wang XC, Zhang JL, Chen S, Huang QC, Fang YF, Wu QJ, He DY, Li ZB, Wang Y, Jiang H, Gao ML, Liu W, Liu Y, Li ZG, Zhao ZW, Wang CW, Liu WC, Wang HD, Lou YQ, Meng QL, Ruan CJ, Xie YM, Jiang Q. Chinese Patient Reported Index with Rheumatoid Arthritis (CPRI-RA): Reliability, Validity and Agreement with DAS28 and HAQ [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/chinese-patient-reported-index-with-rheumatoid-arthritis-cpri-ra-reliability-validity-and-agreement-with-das28-and-haq/. Accessed June 2, 2020.
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