Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: There is very limited data on the clinical, biological characteristics and evolution of primary Sjögren syndrome (pSS) in black patients of African origin. And yet, other connective tissue diseases such as lupus have particularities in this population.
Methods: Retrospective study of all pSS patients fullfiling American-European consensus criteria followed as out and in patients in the rheumatology and internal medicine units from the academic hospital of Fort de France, Martinique.
Results: 70 patients were recruited since 1991 : 68 women, 2 men (female:male ratio, 34:1). Mean age at diagnosis was 49.5 yo (range: 17- 74). Mean follow up time was 3.5 years (range 1-17). Main characteristics were: xerostomia 82.8 % (n = 58) , xerophtalmia 91.4 % (n=64). Objective ocular tests were found positive in 70.3 % (n= 45/64). The minor salivary gland biopsy was positive in 92.5 % (n = 62/67). Other characteristics were: Raynaud’s phenomenon 29.8 % (n = 20/67), arthralgia 55.7 % (n=39), arthritis 21.4 % (n= 15), interstitial lung diseases 8.5 % (n= 6), peripheral neuropathy 8.5 % (n=6), central nervous system involvement 5.7 % (n = 4), pericarditis 1.4% (n=1), pleurisy 2.8 %(n =2), vasculitis 1.4 % (n =1), no pancreatitis. Some other auto-immune diseases were associated to pSS: anti-phospholipid syndrome 7.1 % (n =5), thyroiditis 7.1% (n =5), Evans syndrome 1.4 % (n =1). Antinuclear antibodies were positive for 86.9 %, anti-SSA for 62.8 % (n=44). ESR or c reactive protein were elevated in 33 patients (47.1 %). HTLV-1 positivity was present in 2 patients. In 245 patients. years of follow up, 1 patient experienced lymphoma (0.4 lymphoma for 100 patients.years of follow up). No death was to deplore.
Conclusion: This is the first series of pSS available concerning patients of African origin. Compared to the largest Caucasian pSS cohort published by Ramos Casals et al, there seems to be no major particularities, but men are less frequently suffering from pSS and vasculitis seems less frequent than in the Caucasians.
Disclosure:
K. Polomat,
None;
S. Arfi,
None;
L. Brunier-Agot,
None;
V. Dehlinger,
None;
M. DeBandt,
None;
G. Jean Baptiste,
None;
C. Deligny,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/characteristics-of-primary-sjogren-syndrome-in-the-black-population-of-martinique/