ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1285

Changes in Nail-fold Capillary Abnormalities, and Serum FGF and VEGF Levels in Dermatomyositis Patients with anti-MDA5 Antibody During the Clinical Course

Yasuhito Hamaguchi1, Takashi Matsushita 1, Naoki Mugii 2 and Kazuhiko Takehara 1, 1Department of Dermatology, Kanazawa University, Kanazawa, Japan, 2Kanazawa University Hospital, Kanazawa, Japan

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ,

Session Information

Date: Monday, November 11, 2019

Title: Muscle Biology, Myositis & Myopathies Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Capillary abnormalities in the nail-fold are a characteristic finding of microangiopathy in autoimmune connective tissue diseases, including dermatomyositis and systemic sclerosis. A previous study reported an association between nail-fold capillary findings and disease activity in patients with dermatomyositis. To examine the changes in nail-fold capillary abnormalities, and serum fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) levels in dermatomyositis patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) during the clinical course.

Methods: Capillary abnormalities were evaluated by capillaroscopy in 11 patients with anti-MDA5 Ab at baseline and after treatment. Capillary abnormalities included
irregularly enlarged capillaries,
reduced capillaries,hemorrhage,capillary ramifications, disorganization of the vascular array, loss of capillaries, and giant capillaries. Serum levels of FGF and VEGF were measured by ELISA.

Results: At baseline, i rregularly enlarged capillaries were observed in 10 of 11 cases, but after treatment, they were significantly reduced in only 3 cases (91% vs 27%, p < 0.001). Hemorrhage was observed in all cases at baseline, but disappeared in all cases after treatment (100% vs 0%, p < 0.001). Although the difference was not significant, reduced capillaries slightly improved (58% vs 33%, p = 0.219). Serum FGF levels significantly increased between baseline and after treatment (0.5 ± 0.8 pmol/L vs 1.0 ± 0.6 pmol/L, p < 0.005), but serum VEGF levels were comparable between baseline and after treatment (382 ± 330 pg/ml vs 302 ± 200 pg/ml, p = 0.11).

Conclusion: These data suggest that capillary abnormalities are reversible and improved by treatment. In addition, F
GF may function in the pathophysiology of microvascular abnormalities in dermatomyositis patients with anti-MDA5 Ab.


Table

Table 1

Disclosure: Y. Hamaguchi, None; T. Matsushita, None; N. Mugii, None; K. Takehara, None.

To cite this abstract in AMA style:

Hamaguchi Y, Matsushita T, Mugii N, Takehara K. Changes in Nail-fold Capillary Abnormalities, and Serum FGF and VEGF Levels in Dermatomyositis Patients with anti-MDA5 Antibody During the Clinical Course [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/changes-in-nail-fold-capillary-abnormalities-and-serum-fgf-and-vegf-levels-in-dermatomyositis-patients-with-anti-mda5-antibody-during-the-clinical-course/. Accessed .

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