Date: Friday, November 6, 2020
Session Type: Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: Adult onset Still’s disease (AOSD) is a rare systemic inflammatory disease characterized by a high spiking fever, evanescent rash, arthralgia, generalized lymphadenopathy, and leukocytosis. The activation of innate immune system is the main pathogenesis of AOSD. Chemokine C-C motif ligand (CCL) 2 and CC chemokine receptor (CCR) 2, a ligand of CCR2, have a chemical attractant activity and migrate monocyte and macrophages to the site of inflammation.
Methods: This study checked the serum levels of CCL2 and CCR2 in patients with AOSD and rheumatoid arthritis (RA), and healthy controls (HC), and analyzed their associations with clinical markers in patients with AOSD.
Results: The levels of CCL2 in serum were significantly increased in patients with AOSD (476.41 ± 689.06 pg/mL) compared in patients with RA (169.15 ± 118.71 pg/mL, p = 0.007) and HCs (135.14 ± 71.66 pg/mL, p = 0.003). The levels of CCR2 in serum were increased in AOSD patients rather than RA and HC, but it was not statistically significant because the large variation between individuals. The levels of CCL2 in serum was significantly increased in active group (589.49 ± 772.41 pg/mL) than inactive group (157.73 ± 71.02 pg/mL, p < 0.001) in patients with AOSD. The levels of CCL2 in serum correlated with systemic score (r = 0.539, p < 0.001), the counts of leukocyte (r = 0.316, p = 0.041) and neutrophil (r = 0.316, p = 0.041), C-reactive protein (r = 0.321, p = 0.044), ferritin (r = 0.607, p < 0.001), LDH (r = 0.597, p < 0.001) and albumin (r = -0.428, p = 0.005). However, the level of CCR2 in serum was not associated with any clinical markers of disease activity. After disease was resolved, the levels of CCL2 were significantly decreased in patients with AOSD (p = 0.029).
Conclusion: Circulating CCL2 was elevated in patients with AOSD and was associated with disease activity, suggesting that CCL2 might take a role in the inflammatory response of AOSD.
To cite this abstract in AMA style:Jung J, Kim J, Suh C, Kim H. CCL2 and CCR2 in Adult Onset Still’s Disease [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/ccl2-and-ccr2-in-adult-onset-stills-disease/. Accessed October 20, 2021.
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