Background/Purpose : Our aim was 1) to analyze the association between demographic and traditional cardiovascular risk factors (CVRF) and cardiovascular disease (CVD) in subjects affected with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis (Ps), psoriatic arthritis (PsA), Crohn’s disease (CD), or ulcerative colitis (UC), and 2) to compare the standardized prevalence of CVD among these conditions.

Methods : Subjects included in this cross-sectional study were collected as part of the Immune-Mediated Inflammatory Disease Consortium between 2007-2010. Demographic and clinical data was collected using standardized questionnaires during a clinical interview with close questions and review of medical records. Multivariate logistic regression models adjusted by demographic (gender, age, educational level, elapsed time from IMID diagnosis) and traditional CVRF [dyslidepemia (DL), type 2 diabetes (T2D), obesity (OB), ever smoking] were constructed for each IMID. Results for each variable were combined using inverse variance weighted metaanalysis. Standardized prevalence for each IMID, adjusted by demographic and traditional CVRF [per 100 patients, with 95% confidence intervals (CI)] was calculated using marginal analysis.

Results: 9951 patients were included (Table 1). Table 2 shows the association between demographic and traditional CVRF and CVD in each IMID. When results from the 6 cohorts were combined, males, lower educational level, older age and more time elapsed from disease diagnosis, and presence of DL and T2D were independently associated with a higher risk of CVD. SLE exhibited the highest standardized prevalence, followed by RA, Ps, CD, PsA and UC (Figure 1).

Conclusion : The contribution to CV risk of demographic and traditional CVRF is different for each IMID. SLE showed the higher standardize prevalence of CVD when compared to other IMIDs.