Session Type: ACR Concurrent Abstract Session
Session Time: 11:00AM-12:30PM
Background/Purpose: Even though clinically significant heart involvement is rare, cardiovascular complications are leading causes of death in systemic vasculitis (SV). The comprehensive analysis of histopathologic findings is needed to elucidate the driving mechanisms of increased cardiovascular risk in SV. The purpose of this study was to investigate the variation of cardiac pathological findings in autopsy cases of Takayasu arteritis (TAK), polyarteritis nodosa (PAN) and granulomatosis with polyangiitis (GPA).
Methods: Microscopic examinations of the heart were performed in 108 autopsy cases of SV over a period of 15 years, of which 37 were PAN, 60 – TA and 11 – GPA.
Results: The destructive-productive vasculitis affecting myocardial, epicardial medium and small-sized arteries was observed in 81.1% cases of PAN. The most common acute change was
The pathological changes in coronary vessels have been found in all cases of GPA. The destructive-productive vasculitis affecting intramyocardial small arteries, arterioles, and capillaries was the most common. The acute stage has been characterized by abnormalities of the vessel wall from mucoid swelling to fibrinoid necrosis. The chronic lesions were characterized by intimal hyperplasia, fibrosis, hyalinosis of the vessels with their luminal narrowing. The most common lesion of
Our data show high frequency (76.7%) of pathological changes of coronary arteries in TAK such as intimal hyperplasia, granulomatous arteritis, and coronary atherosclerosis. Intimal hyperplasia consists of areas of
Conclusion: Our data suggest that cardiac involvement is common in SV with a wide range of acute and chronic changes and can be potentially life-threatening.
To cite this abstract in AMA style:Zimba O, Bahrii M. Cardiac Involvement in Systemic Vasculitis: A Retrospective Pathological Study [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/cardiac-involvement-in-systemic-vasculitis-a-retrospective-pathological-study/. Accessed August 24, 2019.
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