Session Type: Abstract Submissions (ACR)
Background/Purpose: The currently available clinical markers are not reliable predictors of long-term progression of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). In a previous study conducted in the GENISOS (Genes versus Environment in Scleroderma Outcome Study) cohort, none of the baseline clinical variables (including serology and disease type) was predictive of long-term decline in forced vital capacity (FVC). Elevated C-reactive protein (CRP) levels have been reported in a subset of patients with SSc and correlated with disease severity as well as shorter survival. Herein, we examine the predictive significance of CRP for progression of ILD (based on longitudinally obtained serial FVC) and survival in a large early SSc cohort.
Conclusion: In the present study, we show for the first time that the baseline CRP levels are predictive of long-term ILD progression. High CRP levels can identify the subgroup of patients that would benefit from more intensive monitoring and treatment.
M. D. Mayes,
J. D. Reveille,
E. B. Gonzalez,
B. E. Harper,
H. T. Draeger,
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/c-reactive-protein-predicts-long-term-progression-of-interstitial-lung-disease-and-survival-in-patients-with-early-systemic-sclerosis/