Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Many rheumatic diseases predominantly affect women in their reproductive years, and have a significant impact on childbearing, but its burden remains incompletely understood. The study aimed to identify the prevalence and incidence of rheumatic diseases among Korean women in childbearing years, and the effect of the diseases on prevalence of comorbidities, and pregnancy rate.
Methods: From National Health Insurance Service-National Sample Cohort (NHIS-NSC) data during 2010-2013, we identified 210,328 women aged between 20-44 years. Among these women, we estimated the prevalence and incidence of rheumatic diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Prevalence of chronic diseases such as cancer (Ca), hypertension (HT), hyperlipidemia (HLD), and diabetes mellitus (DM) was compared in women with or without rheumatic diseases. We also investigated pregnancy rate in women with rheumatic or chronic diseases, and control subjects without rheumatic or chronic diseases.
Results: Total prevalence of rheumatic diseases in childbearing years during 2010-2013 was 0.43%. Total incidence during 2010-2013 was 9.37 cases per 10,000 person-years. Women with rheumatic diseases had significantly higher association with chronic diseases compared with those without (28.38% vs 10.19%, p=<0.001), and had increased risk for HT (OR 3.24, p<0.001) and HLD (OR 3.25, p<0.001). Pregnancy rate was significantly lower in women with rheumatic diseases compared with the control (12.60% vs 18.69%, p<0.001). Among women with rheumatic diseases, women with RA (OR 0.44, p<0.001) were less likely to become pregnant, whereas women with SLE and AS had comparable rate of pregnancy compared with the normal control. Likelihood of becoming pregnant in women with RA is comparable with women with Ca (OR 0.49, p<0.001), HT (OR 0.76, p<0.001), and HLD (OR 0.48, p<0.001).
Conclusion: Rheumatic diseases are a significant burden for women in childbearing years causing increased co-morbidities and reduced pregnancy rate.
To cite this abstract in AMA style:Chung MK, Lee J, Ha EH, Shin JY. Burden of Rheumatic Disease Among Korean Women in Childbearing Years Based on the National Health Insurance Service-National Sample Cohort [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/burden-of-rheumatic-disease-among-korean-women-in-childbearing-years-based-on-the-national-health-insurance-service-national-sample-cohort/. Accessed April 17, 2021.
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