Session Type: Poster Session (Tuesday)
Session Time: 9:00AM-11:00AM
Background/Purpose: In rheumatoid arthritis (RA), it has been reported that osteoclast are activated by immune complexes, anti-CCP antibodies (ACPAs), and inflammatory cytokines. The purpose of this study was to investigate the relationship between bone microstructure and joint involvement by imaging the distal radius using HR-pQCT.
Methods: Subjects were 127 female patients with RA, who were examined with X-ray and HR-pQCT. The patients were divided into the group with no RA change (erosion) in the wrist joint (E(-), Steinbrocker Stage I, N=80, 58+/-12 years old) and the group with RA change in the wrist joint (E(+), Steinbrocker Stage II and III, N=47, 59+/-15 years old). Seventy nine patients with APCA negative unclassified arthritis (UCA) (57+/-10 years old) was used as a disease control group. The distal radius, 9mm away from the distal end of the radius, was scanned with HR-pQCT. Parameters representing bone microstructure were measured separately in the cortical bone, trabecular bone, and the total bone. Statistical significant level was set at p< 0.05.
Results: The total volumetric bone mineral density (vBMD) and trabecular vBMD were significantly lower in E(-) and E(+) than in UCA. The cortical vBMD was significantly lower in E(+) than in E(-) and UCA. The cortical porosity and cortical pore diameter, measures of cortical microstructures, were significantly larger in E(+) than in E(-) and UCA. The trabecular measures such as trabecular bone volume fraction and trabecular number were lower in E(-) and E(+) than in UCA, while they were lower in E(+) than in E(-). Trabecular separation was larger in E(-) and E(+) than in UCA. There was no significant difference in trabecular thickness among the three groups.
Conclusion: In E(+) the porosity of the cortical bone was increased, and the cause of this was considered to be the effect of hand arthritis. In E(-) bone loss was observed in the trabecular bone but not in the cortical bone, suggesting the elevation of non-arthritic bone resorption.
To cite this abstract in AMA style:Tanaka I, Kato T, Mizuno H, Hibi R, Kai M, Ogawa K, Ohshima H, Tamaki S. Bone Microstructure of Patients with Rheumatoid Arthritis: A HR-pQCT Study [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/bone-microstructure-of-patients-with-rheumatoid-arthritis-a-hr-pqct-study/. Accessed April 17, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/bone-microstructure-of-patients-with-rheumatoid-arthritis-a-hr-pqct-study/