ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2304

Bone Microstructure of Patients with Rheumatoid Arthritis: A HR-pQCT Study

Ikuko Tanaka1, Takashi Kato 2, Hiroaki Mizuno 3, Ryosuke Hibi 3, Motoaki Kai 4, Kunikazu Ogawa 4, Hisaji Ohshima 5 and Shigenori Tamaki 3, 1Nagoya Rheumatology Clinic, Ngoya, Japan, 2National Center for Geriatrics and Gerontology, Obu, Japan, 3Nagoya Rheumatology Clinic, Nagoya, Japan, 4Mie Rheumatology Clinic, Suzuka, Japan, 5National Tokyo Medical Center, Tokyo, Japan

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ,

Session Information

Date: Tuesday, November 12, 2019

Title: RA – Diagnosis, Manifestations, & Outcomes Poster III: Comorbidities

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: In rheumatoid arthritis (RA), it has been reported that osteoclast are activated by immune complexes, anti-CCP antibodies (ACPAs), and inflammatory cytokines. The purpose of this study was to investigate the relationship between bone microstructure and joint involvement by imaging the distal radius using HR-pQCT.

Methods: Subjects were 127 female patients with RA, who were examined with X-ray and HR-pQCT. The patients were divided into the group with no RA change (erosion) in the wrist joint (E(-), Steinbrocker Stage I, N=80, 58+/-12 years old) and the group with RA change in the wrist joint (E(+), Steinbrocker Stage II and III, N=47, 59+/-15 years old). Seventy nine patients with APCA negative unclassified arthritis (UCA) (57+/-10 years old) was used as a disease control group. The distal radius, 9mm away from the distal end of the radius, was scanned with HR-pQCT. Parameters representing bone microstructure were measured separately in the cortical bone, trabecular bone, and the total bone. Statistical significant level was set at p< 0.05.

Results: The total volumetric bone mineral density (vBMD) and trabecular vBMD were significantly lower in E(-) and E(+) than in UCA. The cortical vBMD was significantly lower in E(+) than in E(-) and UCA. The cortical porosity and cortical pore diameter, measures of cortical microstructures, were significantly larger in E(+) than in E(-) and UCA. The trabecular measures such as trabecular bone volume fraction and trabecular number were lower in E(-) and E(+) than in UCA, while they were lower in E(+) than in E(-). Trabecular separation was larger in E(-) and E(+) than in UCA. There was no significant difference in trabecular thickness among the three groups.

Conclusion: In E(+) the porosity of the cortical bone was increased, and the cause of this was considered to be the effect of hand arthritis. In E(-) bone loss was observed in the trabecular bone but not in the cortical bone, suggesting the elevation of non-arthritic bone resorption.

Disclosure: I. Tanaka, None; T. Kato, None; H. Mizuno, None; R. Hibi, None; M. Kai, None; K. Ogawa, None; H. Ohshima, None; S. Tamaki, None.

To cite this abstract in AMA style:

Tanaka I, Kato T, Mizuno H, Hibi R, Kai M, Ogawa K, Ohshima H, Tamaki S. Bone Microstructure of Patients with Rheumatoid Arthritis: A HR-pQCT Study [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/bone-microstructure-of-patients-with-rheumatoid-arthritis-a-hr-pqct-study/. Accessed .

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