ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2221

Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study

Luis Seguro 1, Rosa Pereira 2, Luciana Seguro3, Valeria Caparbo 3, Monica Avila 1, Sandrigo Mangini 1, Iascara Campos 1, Fabio Gaiotto 1, Fabiana Marcondes-Braga 1 and Fernando Bacal 1, 1Instituto do Coracao (InCor), HCFMUSP, Sao Paulo, 2Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Sao Paulo, Brazil, 3Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: 25-hydroxyvitamin D, fractures and DXA, osteoporosis, transplantation

  • Tweet
  • Email
  • Print
Session Information

Date: Tuesday, November 12, 2019

Title: Osteoporosis & Metabolic Bone Disease – Basic & Clinical Science Poster

Session Type: Poster Session (Tuesday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Data on prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatment in this high-risk population.

Methods: Seventy adult patients submitted to HTx were followed for 12 months. Clinical and laboratory parameters, bone mineral density (BMD), body composition, microarchitecture and vertebral fractures were assessed at baseline (intensive care unit discharge), 6 and 12 months. Patients received recommendations regarding calcium intake (1,000mg/day) and vitamin D supplementation (50,000U/week for 3 months, followed by 7,000U/week) after HTx.

Results: At baseline, 27.1% of patients had osteoporosis (T-score ≤-2.5), associated with the length of hospitalization before HTx (p=0.001). BMD decreased in the first 6 months, with partial recovery later. Bone microarchitecture deteriorated, mainly trabecular bone in the first 6 months and cortical bone in the subsequent 6 months. At baseline, 92.9% of patients had vitamin D level < 30ng/mL and 20.0% < 10ng/mL. Patients also had calcium at the lower limit of normal, high alkaline phosphatase, associated with low levels of vitamin D (15.5±9.1 ng/ml). These abnormalities were suggestive of impaired bone mineralization and normalized at 6 months with correction of calcium and vitamin D deficiency. The majority of vertebral fractures were identified at baseline (23.5% of patients). After multivariate analyses, only lower fat mass persisted as a risk factor for vertebral fractures (OR 1.23, 95% CI 1.04-1.47, p=0.012).

Conclusion: Present study showed a high frequency of densitometric osteoporosis, vitamin D deficiency, bone markers abnormalities sugestives of bone mineral defect and vertebral fractures shortly after HTx. Calcium and vitamin D supplementation should be the first step in correcting bone mineralization impairment, before specific osteoporosis treatment. Special attention should be given to patients with long length of hospitalization and low fat mass.


Disclosure: L. Seguro, None; R. Pereira, None; L. Seguro, None; V. Caparbo, None; M. Avila, None; S. Mangini, None; I. Campos, None; F. Gaiotto, None; F. Marcondes-Braga, None; F. Bacal, None.

To cite this abstract in AMA style:

Seguro L, Pereira R, Seguro L, Caparbo V, Avila M, Mangini S, Campos I, Gaiotto F, Marcondes-Braga F, Bacal F. Bone Metabolism Impairment in Heart Transplant: Results from a Prospective Cohort Study [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/bone-metabolism-impairment-in-heart-transplant-results-from-a-prospective-cohort-study/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/bone-metabolism-impairment-in-heart-transplant-results-from-a-prospective-cohort-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology