Date: Sunday, November 5, 2017
Session Title: Orthopedics, Low Back Pain and Rehabilitation Poster
Session Type: ACR Poster Session A
Session Time: 9:00AM-11:00AM
Background/Purpose: To assess the glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with low back pain (LBP) and radiculopathy using glycosaminoglycan chemical exchange saturation transfer imaging (gagCEST).
Methods: 258 lumbar IVDs of 53 participants, 21 healthy volunteers, 19 patients with LBP and 13 patients with radiculopathy (28 female; 25 male; mean age: 45.5 ± 16.7 years; range: 23 – 83 years), were examined with a 3T MRI scanner. Biochemical gagCEST imaging was used to determine the GAG content of each nucleus pulposus (NP) and annulus fibrosus (AF).
Results: Significantly reduced gagCEST values of NP were found in patients with LBP and/or radiculopathy (p < 0.0001) compared to healthy control group. NP gagCEST values were significantly lower in patients with LBP (p < 0.0001) and radiculopathy (p = 0.0005) compared to healthy volunteers, respectively. We saw an association between pain and GAG loss with significantly lower gagCEST values in participants with dorsal pain at examination day (p = 0.0004) and higher pain scores (p < 0.0001) compared to participants without LBP. Participants with body mass index ≥ 25 revealed lower gagCEST values compared to participants with BMI < 25 (p = 0.02).
Conclusion: GagCEST analysis indicated significantly lower GAG values of NP in patients with LBP or radiculopathy, in participants with elevated BMI, current pain at examination day and elevated pain scores.
To cite this abstract in AMA style:Sewerin P, Schleich C, Sengewein R, Schneider M, Ostendorf B. Biochemical Intervertebral Disc Alterations in Patients with Low Back Pain and Radiculopathy [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/biochemical-intervertebral-disc-alterations-in-patients-with-low-back-pain-and-radiculopathy/. Accessed September 18, 2021.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/biochemical-intervertebral-disc-alterations-in-patients-with-low-back-pain-and-radiculopathy/