ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2652

Benefits of Aerobic Training in Patients with Ankylosing Spondylitis Are Not Coupled by Effects On Cytokines: A Randomized Controlled Trial

Fabio Jennings1, Hilda A. Oliveira2, Marcelo C. Sousa1, Vaneska G. Cruz1, Fabio S. Lira3 and Jamil Natour1, 1Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 2Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 3Psicobiology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: Ankylosing spondylitis (AS), cytokines and exercise

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Orthopedics, Low Back Pain, and Rehabilitation

Session Type: Abstract Submissions (ACR)

Background/Purpose: Ankylosing Spondylitis (AS) is a systemic inflammatory disease that causes deterioration of physical capacity. Although exercises remain essential in the treatment, the literature lacks research on the mechanisms by which exercises lead to clinical improvements in patients with AS. The purpose of this study was to evaluate the effects of aerobic exercise on functional capacity, mobility, disease activity, aerobic capacity, quality of life and cytokine levels (TNF-α, IL-1β, IL-6 and IL-10) in patients with AS.

Methods: Seventy patients with a diagnosis of AS, according to New York modified criteria and with stable drug treatment, were included. The patients were randomly allocated in two groups. The intervention group (IG) underwent 50 minutes of walking in the individual anaerobic threshold associated with stretching exercises 3 times a week for 12 weeks. The control group (CG) performed stretching exercises 3 times a week for 12 weeks. The outcome measurements were: functional capacity measured using BASFI (The Bath Ankylosing Spondylitis Functional Index), HAQ-S (Health Assessment Questionnaire for spondyloarthritis) and the 6-minute walking test (6MWT); mobility measured using BASMI (The Bath Ankylosing Spondylitis Metrologyl Index); disease activity by BASDAI (The Bath Ankylosing Spondylitis Disease Activity Index) and ASDAS (Ankylosing Spondylitis Disease Activity Score). Aerobic capacity was evaluated using an incremental cardiopulmonary exercise testing protocol by treadmill. TNF-α, IL-1ß, IL-6 and IL-10 levels were measured using ELISA method. The evaluations were done by a blinded assessor immediately before the randomization, 6 weeks, and 12 weeks after the beginning of the exercise programs. It was used intention-to-treat analysis.

Results: Thirty-five patients were randomized to IG and 35 to CG. Two patients from CG and one patient from IG withdrew because of time availability. At baseline, the groups were homogeneous regarding all clinical and demographic characteristics. There were significant improvements in BASFI, HAQ-S, BASDAI and ASDAS scores in both groups (p < 0.05), but there was no difference between groups. There was no significant improvement of mobility and quality of life in both groups. The IG showed significant improvement in 6MWT compared to the control group (p < 0.001). There was significant increase in VO2 peak and anaerobic threshold (AT) in IG after treatment. In CG, VO2 peak and AT did not change after 12 weeks. There was significant difference between groups in absolute values of  VO2 peak (p=0.049) and O2pulse (p=0.039) at 12 weeks. TNF-α, IL-1ß, IL-6 levels did not change over time in both groups. IL-10 levels decreased in both groups after 12 weeks compared to baseline (p< 0.001), but there was no difference between groups.

Conclusion: Aerobic training and stretching exercises had beneficial effects on functional capacity and disease activity. Aerobic training, in addition to stretching exercises, increased walking distance and cardiopulmonary capacity in patients with AS. Aerobic exercise did not affect cytokine levels. More studies are need to understand the mechanisms by which exercises have a therapeutic role in AS.


Disclosure:

F. Jennings,
None;

H. A. Oliveira,
None;

M. C. Sousa,
None;

V. G. Cruz,
None;

F. S. Lira,
None;

J. Natour,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2012 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/benefits-of-aerobic-training-in-patients-with-ankylosing-spondylitis-are-not-coupled-by-effects-on-cytokines-a-randomized-controlled-trial/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology