Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Marine n-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and may be useful in the treatment of psoriatic arthritis. The effects of n-3 PUFA on inflammatory parameters and use of analgesics were examined in patients with psoriatic arthritis.
Methods: Patients with established psoriatic arthritis were included in this randomized, double blind, placebo-controlled study. Patients received the capsules of 3 g n-3 PUFA/d or 3 g olive oil/d for a 24-week period. Clinical status and use of analgesics were assessed as well as leukotriene formation were quantified at baseline and study end.
Results: One hundred and forty-five patients were randomised and 133 completed the study. After 24 weeks of supplementation participants in the n-3 PUFA group showed a significantly higher formation of leukotriene B
Conclusion: The present study, demonstrated a reduction in the formation of the inflammatory leukotriene B
To cite this abstract in AMA style:Kristensen S, Schmidt EB, Schlemmer A, Rasmussen C, Johansen MB, Christensen JH. Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Inflammation and Analgesic Use in Psoriatic Arthritis – a Randomised, Double Blind, Placebo-Controlled Trial [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/beneficial-effect-of-n-3-polyunsaturated-fatty-acids-on-inflammation-and-analgesic-use-in-psoriatic-arthritis-a-randomised-double-blind-placebo-controlled-trial/. Accessed May 30, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/beneficial-effect-of-n-3-polyunsaturated-fatty-acids-on-inflammation-and-analgesic-use-in-psoriatic-arthritis-a-randomised-double-blind-placebo-controlled-trial/