ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1681

Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Inflammation and Analgesic Use in Psoriatic Arthritis – a Randomised, Double Blind, Placebo-Controlled Trial

Salome Kristensen1, Erik Berg Schmidt2, Annette Schlemmer3, Claus Rasmussen4, Martin Berg Johansen5 and Jeppe Hagstrup Christensen6, 1The DANBIO registry and the Danish Departments of Rheumatology, Copenhagen, Denmark, 2Cardiology, Aalborg University Hospital, Aalborg, Denmark, 39Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark, 4Rheumatology, North Denmark Regional Hospital/Aalborg University, Hjoerring, Denmark, 55Department of Cardiology and Unit of Clinical Biostatistics and Bioinformatics, Aalborg University Hospital, Aalborg, Denmark, 6Nephrology, Aalborg University Hospital, Aalborg, Denmark

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords:

Session Information

Date: Monday, November 14, 2016

Title: Spondylarthropathies and Psoriatic Arthritis – Clinical Aspects and Treatment - Poster II: Psoriatic Arthritis

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Marine n-3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects and may be useful in the treatment of psoriatic arthritis. The effects of n-3 PUFA on inflammatory parameters and use of analgesics were examined in patients with psoriatic arthritis.

Methods: Patients with established psoriatic arthritis were included in this randomized, double blind, placebo-controlled study. Patients received the capsules of 3 g n-3 PUFA/d or 3 g olive oil/d for a 24-week period. Clinical status and use of analgesics were assessed as well as leukotriene formation were quantified at baseline and study end.

Results: One hundred and forty-five patients were randomised and 133 completed the study. After 24 weeks of supplementation participants in the n-3 PUFA group showed a significantly higher formation of leukotriene B5 (p < 0.001) and 5-HEPE (p < 0.001) and a significantly lower formation of leukotriene B4 (p = 0.004) compared to controls. Nonsteroidal anti-inflammatory drugs and paracetamol consumption was significantly reduced in the n-3 supplemented group compared to controls (p = 0.04). The n-3 PUFA group also had a significant reduction in disease activity score, tender joint count, enthesitis score and psoriasis area and severity index.

Conclusion: The present study, demonstrated a reduction in the formation of the inflammatory leukotriene B4, increase in the less inflammatory leukotriene B5 and reduction in use of nonsteroidal anti-inflammatory drugs and paracetamol after 24 weeks of n-3 PUFA supplementation. The results suggest that n-3 PUFA supplementation is an attractive adjunctive treatment for patients with psoriatic arthritis. Trial registration: NCT01818804

Disclosure: S. Kristensen, The Danish Psoriasis Foundation, 2,The Danish Rheumatism Association, 2,The Aage Bang Foundation, 2,Heinrich Kopps Foundation, 2,Abbvie Foundation, 2,Jacob Madsen and wife Olga Madsen Foundation, 2; E. B. Schmidt, None; A. Schlemmer, None; C. Rasmussen, None; M. B. Johansen, None; J. H. Christensen, None.

To cite this abstract in AMA style:

Kristensen S, Schmidt EB, Schlemmer A, Rasmussen C, Johansen MB, Christensen JH. Beneficial Effect of n-3 Polyunsaturated Fatty Acids on Inflammation and Analgesic Use in Psoriatic Arthritis – a Randomised, Double Blind, Placebo-Controlled Trial [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/beneficial-effect-of-n-3-polyunsaturated-fatty-acids-on-inflammation-and-analgesic-use-in-psoriatic-arthritis-a-randomised-double-blind-placebo-controlled-trial/. Accessed .

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