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Abstract Number: 1727

Behcet’s Disease: A Meta-analysis of Pregnancy Outcomes

Leah Rooney1, Aine Gorman2, Matthew Turk3, Louise Moore4, Celine O'Brien5, Jared Bierbrier6, Anne Clohessy5, Eamonn Molloy7, Lorraine O Neill8, Fionnuala M. Mc Auliffe5 and Douglas Veale9, 1St Vincent's University Hospital, Dublin, Ireland, 2St Vincents Hospital, Dublin, Ireland, 3St. Vincents University Hospital, Dublin, Ireland, 4Our Lady's Hospice and Care Services, Harold's Cross, Dublin 6W, Kinnegad, Ireland, 5Perinatal Research Centre, Obstetrics and Gynaecology, School of Medicine, University College Dublin and National Maternity Hospital, Dublin, Dublin, Ireland, 6McMaster University, Hamilton, ON, Canada, 7St Vincent's Healthcare Group, Dublin, Ireland, 8St. Vincent's Hospital, Dublin, Ireland, 9University College Dublin, Dublin, Ireland

Meeting: ACR Convergence 2021

Keywords: Behçet's Syndrome, pregnancy

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Session Information

Date: Tuesday, November 9, 2021

Session Title: Reproductive Issues in Rheumatic Disorders Poster (1711–1731)

Session Type: Poster Session D

Session Time: 8:30AM-10:30AM

Background/Purpose: Behcet’s disease is a systemic inflammatory disease which commonly presents with episodes of acute inflammation, oral and genital ulcers, uveitis and skin lesions. It presents most commonly during the second and third decades of life, therefore frequently involves women during their reproductive years. The objective of our work was to determine the effect of Behcet’s disease on pregnancy by evaluating the prevalence of fetal and maternal complications through systematic review and meta-analysis.

Methods: We performed a systematic review of the literature using Medline, Web of Science, and the Cochrane library from their inceptions until March 26, 2021. Studies were included if they presented the frequency of complications in cohorts of pregnant patients with a diagnosis of Behcet’s disease. Studies were selected by two independent reviewers and statistics were performed using REVMAN5.4.

Results: 6638 studies were identified of which 16 were included. Among patients’ with Behcet’s disease during pregnancy the prevalence of caesarean section was 23% (CI 10-36% , Figure 1), pre-term birth 11% (CI 8-15%, Figure 2), miscarriage 11% (CI 8-14%), pre-eclampsia 4% (CI 3-6%), intrauterine death 4% (CI 2-7%), new hypertension 6% (2-10%) and 27% of women reported worsening of symptoms related to Behcet’s disease during pregnancy (CI 20-34 , Figure 3).

Conclusion: Approximately one quarter of patients experienced worsening of symptoms related to Behcet’s disease during pregnancy, 1 in 10 had a pre-term delivery and almost 1 in 4 delivered their baby by caesarean section. These results show the importance of close monitoring of patients with Behcet’s disease during pregnancy – both for pregnancy complications and for worsening Behcet’s symptoms.


Disclosures: L. Rooney, None; A. Gorman, None; M. Turk, None; L. Moore, None; C. O'Brien, None; J. Bierbrier, None; A. Clohessy, None; E. Molloy, None; L. O Neill, None; F. Mc Auliffe, None; D. Veale, Abbvie, 1, 5, 6, BMS, 1, 5, Pfizer, 1, 5, 6, Janssen, 1, 5, 6, Eli Lilly, 1, 5, 6, UCB, 1, 5, 6, Novartis, 1, 5, 6, Galapagos/Gilead, 1, 6.

To cite this abstract in AMA style:

Rooney L, Gorman A, Turk M, Moore L, O'Brien C, Bierbrier J, Clohessy A, Molloy E, O Neill L, Mc Auliffe F, Veale D. Behcet’s Disease: A Meta-analysis of Pregnancy Outcomes [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/behcets-disease-a-meta-analysis-of-pregnancy-outcomes/. Accessed June 1, 2023.
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